This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $489,500 to support structural studies of the full-length nucleocapsid (N) protein of SARS-CoV-2. The goal is to determine the high-resolution structure of the full-length N protein in complex with the viral RNA using cryogenic electron microscopy. This research aims to advance the understanding of the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $130,368 to President and Fellows of Harvard College, doing business as Harvard Medical School, to define how B cell receptor binding site copy number is developmentally regulated to optimize antigen recognition and support affinity-driven antibody selection within B cell germinal centers. The research aims to...
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Grant Program (CFDA 93.855), provides $439,088 to The General Hospital Corporation (Massachusetts General Hospital) to mechanistically define how sex differences in hormones and circulating cytokines modulate B cell class switch recombination, a core immune reaction underlying humoral immunity. The research aims to rigorously elucidate a...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,018,216 to the University of Chicago to conduct research on the contributions of BRWD1-mediated cohesin conversion to B cell biology. The research aims to define BRWD1 functions in germinal centers, determine the mechanisms and importance of BRWD1-mediated GAGA motif recognition, and understand how BRWD1 and cohesin...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $386,194 to the Massachusetts Institute of Technology (MIT) from July 1, 2025 to June 30, 2027. The funding supports the development of "Molecular Tailoring of Bispecific Antibody-Bottlebrush Conjugates", which aims to create new synthetic methods to access bispecific antibody-bottlebrush conjugate (BSABC)...
This federal Project Grant award of $716,281.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Children's Hospital Corporation, doing business as Boston Children's Hospital. The grant supports research to investigate the mechanisms by which T regulatory cells control allergic skin inflammation, particularly in the context of atopic dermatitis. The research aims to understand how the...
This $2,654,646 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports a multi-year program to better understand the unique characteristics of the human immune response in early life. The program aims to uncover genetic and developmental determinants of pediatric immunity, examine how immune parameters evolve over childhood, and elucidate how baseline immune states predict responses to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $808,216.00 to The Children's Hospital Corporation (dba Boston Children's Hospital) from January 2, 2025 to December 31, 2029. The grant supports comprehensive research to elucidate the molecular mechanisms underlying the pathogenesis of tetanus neurotoxin, the sole causative agent of the tetanus disease. Key...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $481,250 to The Broad Institute, Inc. to develop antimicrobial compounds that recruit the immune system to target bacteria. The project will involve biochemical, biophysical, and cell biology experiments to characterize chimeric molecules that combine bacterial binders and immune system protein binders. This research aims to create...