Project Grant R21AI185899

Award Date 7/1/25
Completion Date 6/30/27
Dollars Obligated $407K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $481,250 to The Broad Institute, Inc. to develop antimicrobial compounds that recruit the immune system to target bacteria. The project will involve biochemical, biophysical, and cell biology experiments to characterize chimeric molecules that combine bacterial binders and immune system protein binders. This research aims to create...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $386,194 to the Massachusetts Institute of Technology (MIT) from July 1, 2025 to June 30, 2027. The funding supports the development of "Molecular Tailoring of Bispecific Antibody-Bottlebrush Conjugates", which aims to create new synthetic methods to access bispecific antibody-bottlebrush conjugate (BSABC)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $1,144,714 to the University of Illinois to conduct research aimed at discovering novel antibiotics for gram-negative pathogens. The primary goals are to identify physicochemical traits that allow antibiotics to evade efflux pumps in E. coli, P. aeruginosa, and A. baumannii, and then apply this knowledge to develop at...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $451,000.00 to The Trustees of Princeton University to conduct research aimed at identifying new antimicrobial targets in Gram-negative bacterial pathogens. The key products of this 2-year project involve: 1) Identifying a small molecule inhibitor of methionine synthase that demonstrates chemical synthetic lethality...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) is focused on exploring synergistic combinations of aminoglycoside antibiotics to combat multidrug-resistant (MDR) gram-negative bacteria. The $475,036 award, granted on Apr 11, 2025, aims to: 1) Identify dual-aminoglycoside combinations that demonstrate synergistic and maximally suppressive activity against MDR bacterial isolates, while evaluating...
This Project Grant award of $427,625.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by Washington University to discover novel anti-biofilm agents derived from bacteriophages. The goal is to develop alternative therapies for treating biofilm-associated infections, which are a major challenge for pathogens like Pseudomonas aeruginosa. The research will isolate phages that can overcome biofilm barriers,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $256,995.00 to Tufts University School of Medicine to develop a generalizable strategy for linking quantitative measures of pathogen traits, such as fitness and iron starvation, to host cell mutations using optical sequencing. The project aims to overcome limitations in current approaches for evaluating...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $294,824 to the University of Massachusetts Medical School (UMass Medical) to investigate strategies for enhancing the efficacy of antibiotics against Mycobacterium tuberculosis (MTB) infections. The key objectives are to understand the mechanistic link between glutamine starvation, immune pressure vulnerability, and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $749,417 to President and Fellows of Harvard College to develop novel antibiotic candidates that target the lipoprotein transport pathway in Gram-negative bacteria. The research aims to synthesize and evaluate a modular platform of antibiotics with improved potency and optimized...
This $151,040 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the regulatory role of the small regulatory RNA BECO on essential virulence factors in the pathogen Pseudomonas aeruginosa. The research aims to determine how BECO controls the expression of the Type III Secretion System and pyochelin biosynthesis genes, which are critical for P....

This Project Grant award of $407,156.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to develop new chemical probes to explore the consequences of different complement recruitment strategies for eliminating Gram-negative bacterial pathogens. The key objectives are to: 1) Generate multifunctional compounds that bind to the pathogen Pseudomonas aeruginosa and assess their ability to recruit and kill the bacteria through the classical and lectin-mediated complement pathways; and 2) Evaluate the probes' ability to promote pathogen uptake by immune cells and the impacts on immune cell signaling. This research is anticipated to provide insights into the utility of co-opting the complement system as a novel approach for treating infections caused by antibiotic-resistant Gram-negative bacteria. The award has a period of performance from Jul 1, 2025 to Jun 30, 2027 and is being provided to the Massachusetts Institute of Technology (MIT).

Generated 8/5/25, 3:32 AM