This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $239,120 to Tufts University School of Medicine to analyze the heterogeneity of cell death responses in influenza virus-infected cells. The research aims to understand the interplay between transcriptional programs and different forms of cell death during viral infection, with the goal of elucidating which cell death...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $350,000 in funding to the University of Washington to support research on the transcriptional outputs of the necroptotic cell death pathway. The research aims to define the specific interactions and transcriptional programs activated by necroptosis pathway components, study the role of necroptosis activation in...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $3,258,391 in funding to the University of Massachusetts Medical School to study the role of RNA splicing factors RAVER1 and PTBP1 in regulating cell death, inflammation, and immune responses. The researchers will examine how these splicing factors control the expression and splicing of the RIPK1 protein, which is a...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $784,217 to the Research Foundation of the City University of New York (RFCUNY) - Lehman College to conduct research characterizing how cellular death signaling pathways contribute to both protective and injurious inflammation during bacterial infections. The research aims to identify novel signaling mechanisms...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $492,000.00 to The Regents of the University of California, San Francisco (UCSF) to conduct systematic genetic research on the mechanisms governing immunogenic cell death (ICD). The research aims to decipher the signaling pathways and molecular processes that regulate the immune system's ability to recognize...
This federal Project Grant award of $479,249, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to study the molecular mechanisms regulating neutrophil proinflammatory activity in sepsis. The key objectives are to: Determine the molecular basis of neutrophil A20 signaling in regulating neutrophil proinflammatory function under septic conditions. Utilize two-photon intravital...
This federal Project Grant award of $774,881, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop cell death mechanism-based small molecule host-directed therapies (HDTs) to shorten tuberculosis (TB) treatments and prevent post-TB lung disease. The award supports research by The Johns Hopkins University to explore the use of the pro-apoptotic drug navitoclax as an HDT approach,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $221,888 to the University of New Mexico Health Sciences Center from January 2025 to December 2026. The grant supports research to explore mechanisms for inducing apoptosis (programmed cell death) in Th17 cells, which play a pathogenic role in inflammatory and autoimmune diseases despite their function in...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $412,500 Project Grant to the University of South Florida. The grant, which runs from June 1, 2025 to April 30, 2030, supports research to elucidate the molecular mechanisms of cell death and develop small molecule inhibitors to treat diseases associated with dysregulated cell death, including systemic inflammatory response syndrome, infection, and...
This Project Grant award of $256,995.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop a generalizable strategy for linking quantitative measures of bacterial pathogen traits to host cell mutations. The principal investigator at Tufts University School of Medicine will use optical sequencing techniques to identify host cell gene mutations that impact the growth and iron...