This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $147,656 to The Medical College of Wisconsin, Inc. to conduct a multi-disciplinary analysis of the role of PagC, a protein involved in the biogenesis of bacterial outer membrane vesicles (OMVs). The research aims to define the molecular mechanisms by which PagC induces OMV formation through conformational changes in...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $785,511 to the University of Chicago to conduct research on the genetic and epigenetic basis of inter-individual variation in immune responses to two deadly infectious agents, Mycobacterium tuberculosis and influenza virus. The key objectives are to: (1) characterize variability in immune responses to these...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $189,150.00 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to identify new mediators of proinflammatory cytokine signaling. The goal is to better understand how interleukin-1β (IL-1β) and tumor necrosis factor-α (TNFα) compromise Akt signaling, which regulates a range...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $222,708 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to elucidate the mechanisms driving the development of chronic Chikungunya virus (CHIKV) arthritis. The funded research aims to: (I) define a viral reservoir in macrophages in joint-associated...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $249,000.00 to the Regents of the University of Minnesota to define the mechanisms by which macrophages restrict the bacterium Klebsiella pneumoniae (KP) during bloodstream infections (bacteremia). The research aims to 1) understand how splenic macrophages restrict KP during bacteremia, 2) elucidate host pathways of KP...
This Project Grant award, totaling $902,964.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research to evaluate mechanisms that restrain or enhance alveolar macrophage (AM) responses to Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, with the goal of understanding the regulation of early events during MTB infection. The key...
This federal Project Grant award of $643,718 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how interferon-regulatory factors (IRFs) and STAT transcription factors remodel the epigenome and chromosome organization of macrophages to reprogram their immune responses. The research aims to: 1) dissect the roles of innate immune IRFs in de novo enhancer formation, 2)...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $258,200 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The grant supports research to investigate the non-catalytic functions of HIV-1 integrase (IN) during virion maturation, including developing a biochemical model system to examine IN's ability to encapsulate viral RNA within capsid-like particles and determining cryo-EM structures of IN...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on elucidating the role of Akkermansia muciniphila in Group B Streptococcal (GBS) vaginal colonization and ascending infection. The $148,568 award will support research to investigate the specific mechanisms by which A. muciniphila promotes GBS interaction with human vaginal epithelial cells, potentially...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $226,641 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The grant, awarded on December 5, 2024 with a completion date of November 30, 2026, will support research to examine how the intestinal microbiome and the pattern recognition receptor NOD2 expressed in intestinal epithelial cells impact pathogenesis of Coxsackievirus B3, an enteric virus...