The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Vermont & State Agricultural College (UVM) in the amount of $438,983. The award, which runs from July 8, 2025 to June 30, 2027, will fund research to study the biological impact of a stable nucleocapsid (N) protein dimer formation in SARS-CoV-2. Specifically, the research aims to characterize viral growth kinetics, fitness, and transmission in relation to the N protein dimer in in vitro and in vivo models. Additionally, the project will use proteomics to investigate how the N protein's cellular and viral binding partners are affected by the disulfide bond that stabilizes the dimer. This research seeks to understand the potential growth advantage conferred by the N protein dimer formation observed in several SARS-CoV-2 variants of concern.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $439.0k | 7/8/25 |