Project Grant R21AI183054

Award Date 7/8/25
Completion Date 6/30/27
Dollars Obligated $439K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Vermont, USA
Similar Awards
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $188,544 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Iowa. The grant will fund research to better understand the molecular mechanisms underlying SARS-CoV-2 infection and innate immune regulation. Specifically, the project aims to examine the role of the protein SAMHD1 in regulating SARS-CoV-2-induced inflammation in primary human airway epithelial cell...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $204,347 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Vermont & State Agricultural College to study the intracellular colonization strategies of Salmonella enterica serovar Typhimurium within human intestinal epithelial cells and macrophages. The research aims to characterize bacterial and host transcripts during Salmonella infection, distinguish between cytosolic and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $437,895 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Research Foundation For The State University Of New York (RF SUNY) to investigate the role of the 90K protein in SARS-CoV-2 infection. The key objectives are to provide mechanistic evidence on the effect of 90K during SARS-CoV-2 infection and to identify how SARS-CoV-2 accessory proteins may counteract 90K's antiviral activity. This...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $489,500 to support structural studies of the full-length nucleocapsid (N) protein of SARS-CoV-2. The goal is to determine the high-resolution structure of the full-length N protein in complex with the viral RNA using cryogenic electron microscopy. This research aims to advance the understanding of the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $408,865 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Vermont & State Agricultural College. The grant supports the development of new tools to study how the protozoan parasite Toxoplasma gondii delivers its "rhoptry effector" proteins into host cells during the invasion process. The goals are to: 1) Develop an assay to test whether the rhoptry...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $867,563 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Rockefeller University. The grant supports the development of a pioneering class of nanobodies engineered from llama immune systems to provide comprehensive protection against all betacoronaviruses, including SARS-CoV-1, MERS-CoV, and SARS-CoV-2. Key goals include strategically expanding nanobody repertoires, identifying...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $33,116,067 Cooperative Agreement to the University of California, Irvine (UCI) for the "Allergy and Infectious Diseases Research" program (CFDA 93.855). The award, titled "The UCI Vaccines for Pandemic Preparedness Center (VPPC)", aims to conduct basic and translational research to develop prototype vaccines against emerging viruses. The project will characterize and compare two universal,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $226,641 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The grant, awarded on December 5, 2024 with a completion date of November 30, 2026, will support research to examine how the intestinal microbiome and the pattern recognition receptor NOD2 expressed in intestinal epithelial cells impact pathogenesis of Coxsackievirus B3, an enteric virus...
This Project Grant award of $217,337 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the role of the SARS-CoV-2 ORF9B protein in virus replication. The research aims to investigate the impact of ORF9B phosphorylation on SARS-CoV-2 replication and generate a detailed interaction map of ORF9B during infection, in order to provide significant insights into the biological...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $247,750 to support structural investigations of the SARS-CoV-2 spike protein. The research aims to characterize how glycosylation (the addition of sugar molecules) of the spike protein affects its structure and function, which is critical for virus entry and immune system interactions. This research will...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Vermont & State Agricultural College (UVM) in the amount of $438,983. The award, which runs from July 8, 2025 to June 30, 2027, will fund research to study the biological impact of a stable nucleocapsid (N) protein dimer formation in SARS-CoV-2. Specifically, the research aims to characterize viral growth kinetics, fitness, and transmission in relation to the N protein dimer in in vitro and in vivo models. Additionally, the project will use proteomics to investigate how the N protein's cellular and viral binding partners are affected by the disulfide bond that stabilizes the dimer. This research seeks to understand the potential growth advantage conferred by the N protein dimer formation observed in several SARS-CoV-2 variants of concern.

Generated 8/5/25, 6:27 AM