This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to Pennsylvania State University, doing business as Penn State Milton S. Hershey Medical Center, supports a 2-year research project focused on understanding the role of intestinal barrier function and immune tolerance in inflammatory bowel diseases. The $202,245 award aims to investigate the mechanisms by which the absence of the aryl hydrocarbon receptor (AhR) affects intestinal epithelial permeability and immune homeostasis. The proposed studies in an AhR-deficient mouse model will provide insights into how paracellular permeability influences gut immune responses, which could inform new therapeutic approaches for inflammatory bowel diseases and other immune-mediated disorders.
Generated 3/4/25, 7:15 AM