The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $173,030 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to President and Fellows of Harvard College. The grant, awarded on September 25, 2024, will fund the development of a novel assay for targeted isolation of environmental bacteriophages (phages) based on their receptor dependencies. The project aims to create a generalizable technique that allows selecting phages that require...
This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $197,646 to the University of California, San Diego (UC San Diego) to conduct research on enhancing bacteriophage function with coevolution and synthetic biology. The overall objective is to use experimental evolution to identify genetic changes in phages that enhance their ability to suppress bacterial growth,...
This Project Grant award of $427,625.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by Washington University to discover novel anti-biofilm agents derived from bacteriophages. The goal is to develop alternative therapies for treating biofilm-associated infections, which are a major challenge for pathogens like Pseudomonas aeruginosa. The research will isolate phages that can overcome biofilm barriers,...
This Project Grant award of $106,446 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) aims to establish an innovative, high-throughput method for identifying bacteriophages (phages) and their bacterial host cells within complex microbial communities like the human gut microbiome. The principal investigator will adapt a single-cell RNA sequencing (scRNA-seq) protocol to rapidly screen bacterial cells...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $233,736 to Washington University in St. Louis to elucidate how the DARG1 antitoxin senses and responds to bacterial virus (phage) infection. The research aims to determine which phage DNA metabolism processes are necessary for DARG1 to detect infection, and which DNA processes are sufficient to trigger DARG1's reaction in the absence...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $256,995.00 to Tufts University School of Medicine to develop a generalizable strategy for linking quantitative measures of pathogen traits, such as fitness and iron starvation, to host cell mutations using optical sequencing. The project aims to overcome limitations in current approaches for evaluating...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $229,411 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Northwestern University to investigate Neisseria gonorrhoeae double-stranded bacteriophage. The research aims to determine whether one or more phage islands can produce phage, explore the regulation of two essential LexA orthologs, and assess whether these phage(s) can infect Neisseria strains or species. This project builds upon the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), provides $729,010.00 to Texas A&M University to conduct research on bacteriophage (phage) strategies to lyse bacterial cells. The 5-year project aims to characterize the mechanisms of novel phage lysis proteins, including those from phages infecting the human gut microbiome, using genetic, biochemical, and...
This $408,375 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate phage resistance mechanisms in Mycobacterium abscessus (MAB) and assess how these can be leveraged to enhance the efficacy of antibiotic therapy. The overarching goal is to deepen the fundamental understanding of phage-mycobacteria interactions and apply this knowledge to develop...
This federal Project Grant award of $3,768,791.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research focused on understanding the mechanisms of herpesvirus nuclear egress. The principal investigator at Tufts University School of Medicine will conduct structural and functional studies on the nuclear egress complex (NEC) across different herpesvirus subfamilies, visualize the nuclear...