Project Grant R21AI182680
Award Date
6/18/25
Completion Date
5/31/27
Dollars Obligated
$433K
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Indiana, USA
Similar Awards
This $505,238 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to identify skin-associated compounds that can disrupt mosquito landing and biting behavior. The overarching goal is to discover new chemical compounds that can act as improved topical insect repellents compared to DEET, especially for use in tropical regions. The research will involve validating...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $211,038 to The Johns Hopkins University to conduct research targeting a reductive dehalogenase enzyme as a new strategy for controlling mosquito populations. The goal is to explore how inhibition of this enzyme or accumulation of certain halotyrosines can suppress mosquito fertility, as a mechanism orthogonal to...
This Cooperative Agreement award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to engineer paratransgenic bacterial strains that can interfere with the ability of mosquitoes to transmit malaria parasites. The key objectives are to: Engineer paratransgenic strains of Asaia bogorensis bacteria that lack antibiotic resistance genes, are resistant to horizontal transfer, and secrete...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $648,924 to Iowa State University of Science and Technology to conduct research on the role of mosquito extracellular vesicles in malaria parasite killing and immune system priming. The overarching objective is to obtain a mechanistic understanding of how these extracellular vesicles influence mosquito immune...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $504,596 to Indiana University to conduct research on the molecular interactions between the Wolbachia bacteria and its insect hosts. The project aims to identify the Wolbachia "ankyrin repeat" proteins that manipulate host biology to enable Wolbachia infection and persistence, as well as define the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $512,581 to Iowa State University to examine the influence of prostaglandin E2 (PGE2) on cellular and humoral immunity in the mosquito Anopheles gambiae. The key objectives are to: 1) investigate the cellular and transcriptional events following PGE2 activation, 2) examine the mechanisms of PGE2-mediated immune...
This $707,696 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research to identify the specific volatile organic compounds in human body odor that attract the African malaria mosquito Anopheles gambiae. The primary awardee, The Johns Hopkins University, will recruit a human subject cohort in Zambia to characterize the relationships between human skin microbiome composition, volatile compounds in...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $699,814 to Florida International University (FIU) to study the molecular mechanisms of Plasmodium-Anopheles midgut interactions and develop novel transmission-blocking vaccine approaches for malaria. The key objectives are to functionally characterize mosquito and parasite proteins involved in midgut invasion,...
This $441,502 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to advance CRISPR-based genome editing strategies for managing Aedes aegypti mosquito populations. The key objectives are to: Design a CAS12 temperature-dependent system that only requires a single strain containing both CAS12A and guide-RNAs, eliminating the need to maintain and crossbreed two parental strains...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $760,318 to the University of California, Davis to develop and optimize recombinant enhanced antiviral sensors (REAVRs) that broadly inhibit virus replication. The REAVRs combine virus-sensing domains with effector domains from different antiviral proteins, aiming to create broadly-acting antiviral proteins. The...