Project Grant R21AI182540
- This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $406,450 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Harvard T.H. Chan School of Public Health. The grant supports research to develop a continuous in vitro culture system for the Plasmodium vivax malaria parasite. Key objectives include optimizing the production of host reticulocytes (young red blood cells) to support P. vivax growth, iteratively improving culture conditions...
- This $258,644 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research to develop novel 4-aminoquinoline therapeutics against multi-drug resistant Plasmodium falciparum, the deadliest malaria parasite. The grant recipient, Oregon Health & Science University, will use an iterative medicinal chemistry approach to select compounds with potent antiplasmodial activity, favorable pharmacokinetic...
- This Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The $420,750 award to Iowa State University of Science and Technology supports research to elucidate the role of the PfHAP2P2 protein in the sexual reproduction and fertilization process of the malaria parasite Plasmodium falciparum. The researchers aim to delineate the functional importance and cell...
- This Project Grant award of $1,553,810 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to evaluate a genomic surveillance approach for monitoring artemisinin resistance in Plasmodium falciparum malaria in Africa. The project aims to identify genetic mutations and altered biological functions associated with artemisinin resistance, which is a critical concern as resistance emerges...
- This $501,800 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), to The Children's Hospital Corporation (doing business as Boston Children's Hospital) on August 4, 2025. The grant supports research to use cryo-electron tomography to gain new molecular insights into the divergent cell division process of the Plasmodium falciparum parasite, which causes malaria. The research...
- This federal Project Grant award of $426,938, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to explore the combined use of human anti-RH5 monoclonal antibodies and small molecule inhibitors against asexual Plasmodium falciparum malaria parasites. The research aims to assess the potential for additive, synergistic, or antagonistic effects of these combined interventions in...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,808 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis, Missouri. The funding will support research to identify heme-binding proteins in the malaria parasite Plasmodium falciparum and investigate their role in maintaining heme homeostasis. The project aims to better understand how the parasite detoxifies heme, an essential but redox-active...
- This $122,597 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to analyze the function and antibody-mediated inhibition of the malaria vaccine candidate protein PF3D7_1136200. The project aims to characterize this promising but previously uncharacterized blood-stage malaria antigen, with the goal of advancing development of a highly efficacious malaria vaccine. The...
- The Project Grant award R01AI187153 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on identifying genetic factors associated with sexual stage development (gametocyte formation) in the malaria parasite Plasmodium falciparum. The $700,288 award, with a project period from Nov 2024 to Oct 2029, will fund a research project at the University of South Florida to perform...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $202,055.00 to Harvard T.H. Chan School of Public Health to characterize the Plasmodium falciparum apicomplexan amino acid transporter 2 (PfAPAT2) and its proline transport capability. The research aims to understand the role of PfAPAT2 in regulating proline levels in the malaria parasite, which can impact its sensitivity to certain antimalarial drugs. Key objectives include determining PfAPAT2's proline transport function, evaluating its role in the parasite's life cycle, and assessing its potential as a drug target. This award supports critical research to advance the understanding of malaria biology and inform the development of new treatment strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $202.1k | 8/13/25 |