The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $400,347 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Virginia Polytechnic Institute & State University (Virginia Tech) for a project titled "Profiling Malarial Lipid Biosynthesis and Key Acyl-Coenzyme A Synthetase Activities with Fatty Acid Alkynes." The project aims to develop a new approach called "FA Alkyne Profiling" to systematically analyze fatty acid uptake and lipid biosynthesis in the malaria parasite Plasmodium falciparum. This work will provide insights into the roles and specificities of two parasite enzymes, ACS10 and ACS11, that are involved in activating fatty acids, as well as the effects of inhibiting these enzymes. The project period runs from July 2, 2024 to May 31, 2026.
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