Project Grant R21AG096582
- The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
- The National Institute on Aging, part of the Department of Health and Human Services' National Institutes of Health, awarded $3,724,674 under the Aging Research program (CFDA 93.866) to Texas Tech University Health Sciences Center in Lubbock, Texas. The three-year project grant beginning September 15, 2022 will support research into the impacts of microrna-455-3p (miR-455-3p) in Alzheimer's disease. Specifically, the grantee will investigate the neuroprotective effects of overexpressing and...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how aging produces ultrastructural alterations to neuronal autophagy, which is critical for maintaining neuronal homeostasis and function. The $429,000 award to the University of Texas Health Science Center at Houston will be used to accomplish two specific aims over the 2-year project period starting January 1, 2025: Compare the ultrastructural features of axonal autophagic...
- This $310,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by Texas Tech University Health Sciences Center (TTUHSC) to examine how alternative polyadenylation (APA) of mRNAs contributes to the development and progression of Alzheimer's disease (AD). The project has two main goals: 1) to identify APA genes and pathways associated with AD pathology using computational analysis of existing single-cell RNA-sequencing datasets, and 2)...
- This federal Project Grant award of $425,986 from the National Institute on Aging (NIA) under CFDA 93.866 (Aging Research) will investigate how the APOE4 genetic risk factor for Alzheimer's disease affects hippocampal place cell coding in a rat model. The research aims to understand how APOE4 homozygosity disrupts the hippocampal neuronal population dynamics that support memory functions. Specifically, the study will examine how APOE4 impacts theta-coordinated sequences of hippocampal...
- This $145,992 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms underlying the trans-synaptic spreading of pathological tau in the human brain, and the role of amyloid-beta in modulating this process. The research aims to 1) characterize the molecular mechanisms of bivalent tau oligomer binding to healthy human synapses, as a function of amyloid-beta oligomers, and 2) evaluate how the presence or absence of...
- The National Institute on Aging (NIA) awarded a $1,459,072 project grant to the J. David Gladstone Institutes under the Aging Research Federal Grant Program (CFDA 93.866) to monitor and manipulate inhibitory interneuron cell populations in mouse models of Alzheimer's disease. The 2-year project aims to use dual cell-type-specific enhancer-associated adeno-associated viruses (enhancer-AAVs) to independently monitor and control parvalbumin (PVALB) and somatostatin (SST) inhibitory interneurons...
- This Project Grant award of $433,125.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to explore whether extracellular tau protein can modulate neurogenesis through the LRP1 receptor in adult-born granule neurons. The University of Texas Health Science Center at San Antonio is the prime awardee and will conduct this exploratory/developmental research to better understand the role of LRP1 and tau in hippocampal memory function, which is impacted in...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $429,000.00 to the University of Texas Health Science Center at Houston (UTHealth) to study the impact of Alzheimer's disease pathogenesis on the activity of corticotropin releasing factor (CRF) neurons and regulation of the hypothalamic-pituitary-adrenal (HPA) axis. The research aims to identify a direct mechanism connecting Alzheimer's disease progression with dysregulation of the...
- The University of California Irvine will receive $4,522,968 over three years from the National Institutes of Health National Institute on Aging under the Aging Research grant program (CFDA 93.866) to investigate the temporal, spatial and cellular dynamics of amyloid plaque deposition in Alzheimer's disease. The research will utilize cutting-edge biorthogonal non-canonical amino acid tagging technology and cell-specific Cre driver mouse lines to label the proteomes of specific cell types and...
The University of Texas at Austin was awarded a $438,625 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research program) to conduct research on "DECODING THE HETEROGENEITY OF INTERNEURON VULNERABILITY IN AGING AND ALZHEIMER'S DISEASE: AN ULTRAPLEX CLEM APPROACH." The project aims to better understand how different subtypes of inhibitory interneurons in the hippocampus are impacted by aging and Alzheimer's disease, and how some interneurons may be more resilient and contribute to maintaining the balance of excitation and inhibition important for learning and memory. The 2-year project will employ advanced techniques like combinatorial labeling and electron microscopy to comprehensively characterize interneuron populations and subcellular changes during aging. The research seeks to provide new insights into the selective vulnerability of interneurons and identify potential compensatory mechanisms that could inform interventions for age-related cognitive decline and Alzheimer's disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $438.6k | 8/28/25 |