Project Grant R21AG093377
- Federal Grant Award Summary The National Institute on Aging awarded the Regents of the University of Minnesota a $423,500 Project Grant under the Aging Research program (CFDA 93.866) effective February 1, 2026 through January 31, 2028. This award supports basic biomedical research investigating the mechanistic links between cyclin D1 protein expression, metabolic dysfunction, and aging processes. The research will utilize complementary model systems—including hepatocyte studies in mice and...
- Federal Grant Award Summary Fred Hutchinson Cancer Center received a $2.59 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with completion targeted for August 31, 2029. The grant funds fundamental research to elucidate mechanisms of adipocyte-brain communication and their impact on glial function, neuroprotection, and brain aging, with potential implications for preventing dementia and age-related...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Regents of the University of Minnesota $645,743 under the Aging Research program (CFDA 93.866) to conduct a longitudinal epidemiological study examining the relationship between childhood socioeconomic status (SES) and lead (Pb) exposure on dementia risk in later life. The project, spanning February 1, 2026 through December 31, 2030, creates a novel research data source by linking approximately 15,792...
- Federal Project Grant Award Summary The National Institute on Aging awarded the University of Oklahoma Health Sciences Center a $286,000 Project Grant (CFDA 93.866 – Aging Research) effective September 15, 2025, with completion targeted for August 31, 2027. This pilot study delivers novel biomedical research investigating the mechanisms by which age-related lipid dysregulation in brain vascular endothelial cells contributes to cognitive impairment. The research employs single-cell RNA-sequencing...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $2.5 million to the University of Minnesota under the Aging Research program (CFDA 93.866) to conduct a longitudinal research study examining the relationship between housing policy, neighborhood context, and midlife mortality outcomes. Awarded on September 15, 2025, with a completion date of September 14, 2029, this four-year project delivers epidemiological research services that leverage data from the Moving...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $412,500 Project Grant to the University of South Florida (USF) under the Aging Research program (CFDA 93.866) for a two-year research initiative running from June 1, 2025, through May 31, 2027. This grant funds scientific research aimed at identifying novel biomarkers for early diagnosis and prognosis prediction of Alzheimer's disease (AD), a neurodegenerative condition affecting 5.5 million Americans. The project...
- Federal Grant Award Summary The National Institutes of Health Office of the Director awarded $1,311,772 through the Trans-NIH Research Support program (CFDA 93.310) to the Regents of the University of Minnesota, with an award date of September 30, 2025, and completion date of August 31, 2028. This Director's New Innovator Award (DP2) funds research investigating neuroplasticity and cerebral blood flow mechanisms in "fast-moving superagers"—individuals aged 75 and older who maintain...
- Federal Grant Award Summary The University of Pennsylvania received a $446,875 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded January 15, 2026, with a completion date of December 31, 2028. This research project investigates how specific genetic variants and aging jointly influence polyunsaturated fatty acid (PUFA) metabolism in white adipose tissue (WAT) using human-derived induced pluripotent stem cells (iPSCs) differentiated...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $509,413 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025 through May 31, 2030. This award funds scientific research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD), with the primary deliverable being novel research findings and analysis concerning how adenosine methylation...
- Federal Project Grant Award Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $2,991,725 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective September 1, 2025, with a completion date of August 31, 2029. This award funds a comprehensive research initiative investigating reactive oxygen species (ROS) as modulators of lifespan and aging processes. The research examines how early-life...
The University of Minnesota, operating through its Office of Sponsored Projects Administration, received a $423,500 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 1, 2026, through January 31, 2028. The award funds research on the functional characterization of adipocyte-derived lipocalin 2-containing extracellular vesicles in senescence, with research activities conducted in St. Paul, Minnesota. The project will advance understanding of how adipose tissue function affects metabolic health and age-related metabolic diseases. Specifically, the research will investigate the role of lipocalin 2 (LCN2), a phosphatidic acid-binding protein, in regulating intercellular communication through extracellular vesicles secreted by adipocytes and adipose stem/progenitor cells. The study addresses a critical gap in knowledge regarding how senescence impairs adipogenesis and contributes to metabolic dysfunction during aging. Deliverables will include characterization of distinct adipocyte-derived extracellular vesicle subtypes and their functional roles in local and systemic metabolic regulation, with findings intended to support development of interventions targeting age-related metabolic diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 1/16/26 |