Project Grant R21AG093249
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund the development of a novel "theranostic" (therapeutic and diagnostic) Chimeric Antigen Receptor (CAR) T cell platform to detect and target senescent cells associated with Alzheimer's disease and other age-related disorders. The $834,627 award, made on March 19, 2025, supports the University of Florida's research to create unique probes and a signal-sensing chemically-induced proximity...
- This $147,486 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to investigate the role of chaperone-mediated autophagy (CMA) in cellular senescence and its contribution to aging. The research aims to understand: 1) if CMA activity changes upon induction of senescence, 2) if CMA modulates senescence kinetics and by what mechanism(s), 3) if CMA is required for senescent cell clearance, and 4) if restoring CMA activity...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $704,198.00 to Trustees of Dartmouth College from December 1, 2024 to November 30, 2026 to develop chimeric antigen receptor (CAR) T regulatory cells (Tregs) that target aggregated amyloid-beta, a key hallmark of Alzheimer's disease (AD). The goal is to enhance the persistence of these CAR Tregs in the central nervous system to help rebalance cerebral immunity, promote amyloid-beta...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $132,705 Project Grant under the Aging Research program (CFDA 93.866) to The Children's Hospital Corporation (doing business as Boston Children's Hospital). The award aims to conduct research on "Targeting Metabolic Vulnerabilities to Restore Balanced Hematopoiesis During Aging," with a project period from June 15, 2025 to May 31, 2027. The research will use single-cell...
- This $728,370 project grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to develop engineered T cell approaches for treating Alzheimer's disease. The key objectives are to design and develop "CARDINAL" (CAR Disease Interventions for Alzheimer's) T cells that can expand and persist at the site of Alzheimer's pathology, utilizing cytokine signaling in the CAR constructs to release neuroprotective payloads that can modulate the brain...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Sloan-Kettering Institute for Cancer Research in New York aims to understand the cellular mechanisms that regulate lymph node maintenance and atrophy during aging. The $513,957 award will support research to investigate the role of lymphatic endothelial cell NF-κB signaling in adult lymph node homeostasis. Key objectives include determining the effects of aging on lymph node lymphatic...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), aims to study the impact of frailty on disease relapse and therapy intensity in older adults with acute myeloid leukemia (AML). The $243,000 award to the University of Pennsylvania will support research to identify biomarkers and develop treatment selection strategies for this population. The project, running from September 2025 to May 2030, seeks to address the significant disparity in...
- This federal Project Grant award of $3,101,237.00 was provided by the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, under the Aging Research federal grant program (CFDA 93.866). The funding supports a research project investigating the mechanisms linking persistent DNA damage to immune responses and hematopoietic stem and progenitor cell function in the context of aging and DNA repair deficiency. Key objectives of the project include: 1) elucidating...
This Project Grant award of $451,000.00 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will fund research to understand how aging and chronic lymphocytic leukemia (CLL) impact the metabolic function of T cells. The goal is to develop strategies to rescue T cell aging and improve the production of chimeric antigen receptor (CAR) T cells from elderly cancer patients. The award will support cutting-edge metabolism assays to evaluate the effects of natural aging and CLL on CD8 T cell metabolic adaptation after T cell receptor (TCR) and cytokine signaling. The research aims to identify approaches to rebalance TCR and cytokine stimulation to correct the age-associated defects in T cell expansion. This 2-year project, running from September 2025 to August 2027, will be conducted by the University of Texas Southwestern Medical Center in Dallas, Texas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 8/26/25 |