Project Grant R21AG092914
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $522,500.00 to The Salk Institute for Biological Studies to conduct research aimed at understanding the role of astrocytes, a type of non-neuronal brain cell, in contributing to age-related motor and cognitive decline. The key objectives are to determine if the transcription factor STAT1 drives age-related changes in cerebellar astrocytes, and whether modulating STAT1 can prevent or rescue...
- This federal Project Grant award of $2,316,710 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop magnetogenetic techniques for manipulating the activity of specific brain cell types implicated in the onset and progression of Alzheimer's disease (AD). The research will focus on using a magnetogenetic tool called FERIC (Ferritin Iron Redistribution to Ion Channels) in combination with enhancer AAV vectors to non-invasively control the activity of AD-vulnerable...
- This federal Project Grant award of $3,221,450.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to define how neuronal hyperexcitability in the retrosplenial cortex (RSC) contributes to the development of Alzheimer's disease (AD)-related behavioral deficits in mouse models. The research aims to determine the effect of inhibiting RSC layer 5 cells on spatial memory and navigation, as well as when hyperexcitability emerges in these cells across different AD...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- This federal Project Grant award of $2,631,670 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research initiative at The Washington University to investigate age-related deficits in episodic memory. The project aims to determine how aging distinctly affects the content and structure of memory representations, and how this relates to dysfunction in different brain networks based on susceptibility to Alzheimer's disease pathology. The research will utilize plasma...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a $185,074 research study conducted by the University of California, Berkeley. The goal of the study is to examine how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. The researchers will use positron emission tomography (PET) imaging and resting-state functional MRI (rs-fMRI) to investigate the mechanisms of how...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This $461,146 federal project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Yale University supports research to investigate the disruption of astrocytes, a key cell type in the brain, and its relationship to the development of Alzheimer's disease (AD) in animal models. The project aims to utilize novel imaging techniques to longitudinally track changes in astrocytic and neuromodulatory signaling across the cortex in awake behaving animals over the 2-year...
- This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
This federal Project Grant award of $433,125.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports the "Molecular and Cellular Exploration of Striatal Astrocytes in Aging" research project at the University of California, Los Angeles (UCLA). The project aims to investigate how astrocytes, a type of glial cell, change within the striatum region of the brain during the aging process. Specifically, the research will explore age-related molecular and cellular alterations in striatal astrocytes and their role in the disruption of normal striatal function, which can lead to degradation of motor skills and increased susceptibility to age-related neurodegenerative diseases. The award has an initial period of performance from Aug 1, 2025 to Jul 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $433.1k | 7/30/25 |