Project Grant R21AG091272

The National Institutes of Health (NIH) National Institute on Aging (NIA) awarded a $464,750 Project Grant (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on the genetic determinants of transcription factor binding in pooled microglia. The project aims to identify Alzheimer's disease-associated genetic variants that alter the binding of key transcription factors involved in microglial function. The research will utilize techniques such as chromatin immunoprecipitation sequencing (ChIP-seq), RNA sequencing, and massively parallel reporter assays to elucidate the regulatory mechanisms by which Alzheimer's risk variants affect gene expression in microglia. The findings from this 2-year project are expected to further the understanding of how Alzheimer's disease genetics relate to molecular mechanisms in microglia, setting the stage for future mechanistic studies.