Project Grant R21AG088936

The University of North Carolina at Chapel Hill (UNC-CH) received a $440,079 federal Project Grant award (R21AG088936) from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award provides funding for a 2-year proof-of-concept study to validate a new "penta-omic" extraction method that can simultaneously analyze metabolomic, proteomic, lipidomic, DNA, and RNA profiles from a single post-mortem human brain tissue sample. This multi-omics approach aims to minimize variability associated with analyzing multiple tissue samples separately. As part of the project, UNC-CH will create the first penta-omic database using normal brain tissue from the NIH NeuroBiobank. Additionally, UNC-CH is collaborating with the University of Miami, who will help define tissue sample selection criteria and contribute to interpreting the multi-omics analyses.