This Project Grant award from the National Institute on Drug Abuse (NIDA), under CFDA Program 93.279 Drug Use and Addiction Research Programs, provides $3,487,935 to Florida State University to conduct a study examining the effects of long-term medical marijuana use and prescription opioid use on driving performance in adults aged 50 and older with chronic pain. The primary goals are to identify the impacts of daily, long-term medical marijuana use on open-road driving tasks, as well as the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,365,011 to the University of Washington to conduct a clinical trial examining the neuromodulatory mechanisms and moderators of mindfulness meditation (MM) and self-hypnosis (HYP) for chronic pain reduction in older adults. The study will enroll 375 participants and use arterial spin labeling fMRI and EEG to investigate how these non-pharmacological treatments impact chronic pain via...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a $636,957 study to investigate the relationship between prescription opioids, brain structure, and cognition in older adults with chronic pain. The single-center, double-blinded, placebo-controlled trial will enroll 200 participants with chronic pain due to osteoarthritis. The primary goal is to determine if opioid exposure is associated with changes in white matter integrity and global...
The National Institute on Drug Abuse (NIDA) awarded a $137,619 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Washington. The grant, awarded on January 19, 2025, will support research to investigate the role of tetrahydrocannabinol (THC) in mediating pain signaling in the basolateral amygdala (BLA) brain region. The study aims to determine how THC, acting through cannabinoid 1 receptors (CB1R), alters glutamatergic neuronal activity in the BLA...
The National Institute on Aging (NIA) awarded a $676,000 Project Grant under its Aging Research Federal Grant Program (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai. The grant will fund research to study the unintended impact of the 2016 CDC opioid prescribing guidelines on disparities in opioid utilization among vulnerable subgroups of older adults, including those with Alzheimer's and related dementias, racial/ethnic minorities, and those experiencing socioeconomic deprivation....
This federal Project Grant award of $153,000.00 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports a 6-month longitudinal study to examine the relationship between cannabis use, pain perception, and daily functioning in young adults with chronic pain. The research will use an ecological momentary assessment (EMA) design to capture real-time data on cannabis use, pain, physical activity, and sleep over...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,980,270 to the Regents of the University of Minnesota to conduct an observational study on the neurobehavioral impacts of medical cannabis use. The study aims to assess cognition, neural function, and substance use disorder (SUD) risk in 120 medical cannabis patients in Minnesota compared to 60 non-cannabis using controls. It will...
The National Institute on Aging (NIA) awarded a $656,000 Project Grant (CFDA 93.866 - Aging Research) to The Regents of the University of California, San Francisco (UCSF) to investigate the role of hyperalgesic priming in chronic pain experienced by the elderly. The research aims to: 1) establish that aged rats exhibit nociceptor plasticity (priming) and determine if it is associated with systemic inflammation, and 2) identify the mechanisms underlying priming in the elderly, including the...
This $2,249,392 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to validate senescent cells as a target for the treatment of chronic pain in aging. The project aims to rigorously characterize the role of senescent neurons and their senescence-associated secretory phenotype (SASP) in driving dorsal root ganglion hyperexcitability and persistent pain following...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a 5-year, $2,726,432 research study on co-use of cannabis and prescription opioids among emerging adults in medical settings. The study will enroll emerging adults aged 18-25 who either have no history of cannabis use or have used cannabis in the past month and are prescribed an opioid for acute pain management. Participants will be followed...