This federal Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to characterize age-related changes in the testis stem cell niche. The $466,125 award to New York University School of Medicine aims to identify genes differentially expressed in young and aged hub cells, which form the testis stem cell niche, and understand how changes in activin signaling and the extracellular matrix impact niche cell function and number during aging. The research will utilize the adult Drosophila testis as a model system and develop new tools to monitor activin signaling components in vivo. The study is expected to run from September 30, 2024 to August 31, 2026 and advance knowledge about how aging affects niche cell function, which is critical for understanding and treating age-related male infertility.
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