Project Grant R21AG086710
- This $605,486 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to define the mechanisms that coordinate late endosome and lysosome functions in neurons. The research aims to address the significant lack of understanding about how the network of proteins that control lysosome function is integrated to meet the unique demands of neurons. This is a critical barrier to understanding the relevance of abnormal lysosome...
- This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
- This $147,486 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to investigate the role of chaperone-mediated autophagy (CMA) in cellular senescence and its contribution to aging. The research aims to understand: 1) if CMA activity changes upon induction of senescence, 2) if CMA modulates senescence kinetics and by what mechanism(s), 3) if CMA is required for senescent cell clearance, and 4) if restoring CMA activity...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how aging produces ultrastructural alterations to neuronal autophagy, which is critical for maintaining neuronal homeostasis and function. The $429,000 award to the University of Texas Health Science Center at Houston will be used to accomplish two specific aims over the 2-year project period starting January 1, 2025: Compare the ultrastructural features of axonal autophagic...
- This federal Project Grant award of $1,565,823.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant supports research to understand the biological mechanisms underlying the autophagy-lysosome system and its role in cellular quality control and aging processes. The principal investigator at Louisiana State University (LSU) aims to investigate how the dynamic transformation of lysosomes into expanded tubular networks can enhance...
- This Project Grant award of $328,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the Alzheimer's Disease Organelle Proteome Task (ADOPT) pilot phase. The interdisciplinary research team, led by Drs. Biao Wang and Danielle Swaney at the University of California, San Francisco, will use a genetic organelle tagging approach to rapidly purify lysosomes from neurons in wild-type and Alzheimer's disease mouse models. A suite of mass spectrometry experiments will then...
- This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $227,250 to Saint Louis University to conduct research on the role of the protease Cathepsin L in modulating the nuclear proteome, particularly in the context of premature aging disorders and Alzheimer's disease. The key goals are to: 1) elucidate the mechanism by which Cathepsin L modifies the toxic progerin protein that causes Hutchinson-Gilford Progeria...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $921,822 to Yale University to conduct research on the role of the TBK1 gene and its effects on lysosome function in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research aims to elucidate the molecular mechanisms by which TBK1 coordinates lysosome function with cellular demand, including examining the contributions of TBK1...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of Southern California to investigate methods for purging mammalian cells of deleterious mutations in the mitochondrial genome (mtDNA) that contribute to aging and age-related diseases. The research aims to develop new genetic and molecular biology tools, combined with advanced sequencing techniques, to selectively remove harmful mtDNA mutations from...
This $451,000 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research by The University of Texas Southwestern Medical Center to investigate the role of the p38 MAPK signaling pathway in regulating lysosome function and tissue integrity during development and aging. The key goals of this 2-year project are to: 1) define the p38 MAPK interactome required for lysosome regeneration, 2) reveal tissue and stage-specific functions of p38 MAPK in lysosome regeneration and heterogeneity, and 3) delineate the tissue-specific contributions to p38 MAPK cross-tissue signaling. The research will utilize a range of proteomics, genetic, biochemical, and cell biology approaches to understand how p38 MAPK signaling regulates lysosome homeostasis and promotes tissue integrity, with the long-term objective of elucidating the molecular and physiological mechanisms of this pathway during development and aging.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 7/18/24 |