The National Institute on Aging (NIA) awarded a $467,416 Aging Research (CFDA 93.866) Project Grant to Tufts University School of Medicine to investigate the effects of calorie restriction on mitochondrial DNA integrity, biological aging, and cardiometabolic health. The project aims to measure changes in mitochondrial DNA heteroplasmy over a two-year period using samples from the CALERIE clinical trial. The study will examine whether calorie restriction promotes mitochondrial integrity by reducing the accumulation of mitochondrial DNA heteroplasmic mutations, and if these changes are associated with improved biological aging and cardiometabolic profiles. The project includes a $244,622 sub-award to Boston University Medical Campus to provide statistical expertise and support for the research design, analysis, and interpretation. The grant is expected to provide insights into the molecular mechanisms behind the beneficial effects of calorie restriction and the role of mitochondrial DNA in age-related cardiometabolic diseases.
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