This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the Medical College of Wisconsin, Inc. (MCW) to investigate the role of extracellular vesicles and associated Y5-RNA in mediating age-related impairment of angiogenesis. The $847,000 award will fund a study to determine whether decreases in Y5-RNA within endothelial cell-derived extracellular vesicles contribute to endothelial cell senescence and the age-dependent decline in angiogenesis. The project aims to elucidate this mechanism and assess whether manipulating Y5-RNA could potentially reverse the age-related impairment of blood vessel formation, with the goal of developing new therapeutic strategies for age-related diseases.
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