The National Institute on Aging (NIA) awarded The Leland Stanford Junior University (Stanford University) a $428,563 Project Grant under the Aging Research Program (CFDA 93.866) to develop a modular cell-on-chip platform to study how neuronal activity regulates myelin sheath formation and how these dynamics are altered in neurodegenerative disease. The 2-year project will enable fine-tuning of neuronal stimulation, recording of extracellular activity, and high-resolution imaging of myelin morphology in oligodendrocyte-neuron co-cultures. This programmable system will elucidate the neuronal activity patterns that enhance or inhibit myelination, as well as investigate how neuronal activity and myelination are disrupted in models of neurodegenerative conditions like Alzheimer's disease. The researchers plan to share the recorded neuronal activity and myelin-axon data on public repositories, providing an open-access resource for studying activity-dependent myelination in different neuronal circuits and neurodegenerative contexts.
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