This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,018,778 to The Lieber Institute for Brain Development (LIBD) to generate spatially-resolved, transcriptome-wide gene expression profiles of the human dentate gyrus across the lifespan. The project aims to characterize developmental and age-related changes in gene expression within specific subregions of the hippocampus, a critical brain structure involved in learning, memory, and neuropsychiatric disorders. This community resource will enable refined annotation of spatial gene expression patterns and contribute to understanding neurodevelopmental and neurodegenerative processes. The award period runs from September 1, 2023 to August 31, 2025. As a specialized medical research institute, LIBD has a track record of providing brain tissue sequencing, data analysis, and other research services to federal agencies like the VA and DoD under both prime contracts and subcontracts with academic partners.
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