This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to The Roskamp Institute, Inc. in Sarasota, Florida provides $449,460 in funding to support research investigating the role of cerebrovascular dysfunction and bioenergetic deficits in the increased Alzheimer's disease risk associated with the APOE4 genetic variant. The research aims to determine how APOE4 disrupts L-carnitine-mediated bioenergetic pathways in brain endothelial and mural cells, and whether boosting these pathways can help restore nutrient balance in the brain and mitigate the deleterious effects of APOE4. This work is expected to provide insights into therapeutic strategies targeted at APOE4 carriers, who experience a higher cerebrovascular disease burden as part of Alzheimer's pathogenesis. The award period runs from September 1, 2023 through August 31, 2025.
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