Project Grant R21AG077150

Award Date 9/1/24
Completion Date 8/31/26
Dollars Obligated $514K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
미국 뉴욕
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Maryland, College Park to study the biophysical properties of lymph nodes and their impact on immune cell function during the aging process. The $419,170 award, running from August 2024 to July 2026, will utilize advanced microscopy techniques like multiple particle tracking and Brillouin microscopy to characterize changes in the elastic and viscous moduli, pore...
This $351,750 project grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to Yale University. The project aims to elucidate the role of the NLRX1 protein in altering T cell immunity during the aging process. Specifically, the research will investigate the mechanism by which decreased NLRX1 expression augments age-associated changes in T cells, including expansion of memory T cells, decreased naive T cell survival, and...
The National Institute on Aging (NIA) awarded a $1,905,716 Project Grant (CFDA 93.866 - Aging Research) to New York University (NYU) School of Medicine to investigate the molecular mechanisms regulating the inflammatory response in skeletal stem and progenitor cells (SSPCs) and the role of anti-inflammatory factors in resolving inflammation. The research aims to generate insights into the drivers of bone degeneration during aging and identify therapeutic targets to improve bone health and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $133,353 to Mayo Clinic to conduct research on the molecular mechanisms of T cell surveillance and elimination of senescent cells under homeostasis and aging conditions. The key products and services delivered under this 2-year award include: Defining how different types of senescent cells utilize their secretome to sensitize human T cells for activation, survival, and retention (Aim 1)...
This Project Grant award of $859,240.00, provided by the National Institute on Aging under the Aging Research Federal Grant Program (CFDA 93.866), supports research investigating the relationships between immunesenescence, brain aging biomarkers, and cognition across nonhuman primate species with differing lifespans. The primary awardee, The University of Texas MD Anderson Cancer Center, will conduct studies to better understand the role the immune system plays in longevity, neurodegeneration,...
The National Institute on Aging awarded a $1,334,474.00 Project Grant (CFDA 93.866 - Aging Research) to the Regents of the University of Minnesota on June 1, 2024. The grant will fund the development of single-cell analysis methods using mass cytometry techniques to explore molecular pathways and cellular processes related to aging. The key objectives are to: (1) deliver molecular probes to live cells to monitor pathways like protein synthesis and post-translational modification; (2) barcode...
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The National Institute on Aging (NIA) awarded a $1,510,410 Project Grant (CFDA 93.866 - Aging Research) to Mayo Clinic in Rochester, Minnesota to conduct research on characterizing senescent cell populations in the bone microenvironment and their role in age-related bone loss. The project aims to leverage novel mouse models and advanced single-cell analysis techniques to better understand the heterogeneity of p16-positive senescent cells in the bone and their contributions to skeletal aging....
This National Institute on Aging (NIA) Project Grant award under the Aging Research Federal Grant Program (CFDA 93.866) provides $1,055,313 in funding to the University of Miami to conduct research on the role of glial cells in the aging process. The primary objectives are to 1) establish how the glial ion channel CLH-1 influences aging, and 2) identify the tissues and pathways regulated by glial CLH-1 during aging. The grant supports leveraging the power of C. elegans genetics and the...
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