Project Grant R21AA032367
- This federal Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 Alcohol Research Programs), supports research to determine the molecular mechanism by which the neutrophilic NCF1 gene and its downstream target miR-223 impact the pathogenesis of alcohol-associated liver disease (ALD). The $249,000 project, awarded to the Trustees of Indiana University, will investigate how neutrophils drive disease severity and mediate liver injury in ALD through the...
- The federal Project Grant award of $617,748 was provided by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 Alcohol Research Programs) to Cedars-Sinai Medical Center in California. The grant supports research to examine the role of the protein prohibitin 1 (PHB1) in the sensitizing effect of ethanol on colorectal liver metastasis. Specifically, the research aims to investigate how ethanol depletion of nuclear and cytosolic PHB1 in hepatocytes promotes increased expression...
- This Project Grant award of $477,626 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The purpose of the award is to investigate the role of the TET1 enzyme in regulating sex differences in alcohol-associated liver tumorigenesis. The award supports a research project at Tulane University exploring how TET1 affects the development of alcohol-associated liver disease, particularly in female mice....
- This federal Project Grant award of $701,051 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The grant supports research to investigate the phenotypes and functions of distinct neutrophil populations in patients with severe alcohol-associated hepatitis (AH). Key objectives include: 1) Characterizing the transcriptomic profiles and functional roles of neutrophil subsets in AH using single-cell RNA sequencing; 2)...
- This Project Grant award of $123,045.00 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research on the role of the TRAF3IP2 protein in the development of alcohol-related cardiomyopathy. The project will investigate whether alcohol-induced cardiac fibroblast activation, proinflammatory cytokine expression, and extracellular matrix changes are dependent on TRAF3IP2, and whether deleting the TRAF3IP2 gene prevents alcohol-induced...
- This $177,736 Project Grant award was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) located in Massachusetts. The project aims to investigate the role of hepatokines, predominantly hepatocyte-secreted proteins, in the pathogenesis of alcohol-associated liver disease and alcohol-associated hepatitis. Specifically, the research will explore the involvement of the...
- The federal Project Grant award titled "Role of Functional Iron Deficiency in Alcohol-Associated Liver Disease" is funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The $390,480 award, effective from September 10, 2025 to August 31, 2027, will support research at Emory University to investigate the molecular mechanisms underlying alcohol-associated mitochondrial dysfunction and its role in the progression of...
- This federal Project Grant award of $659,865 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research at Yale University to investigate the role of aberrant mitochondrial calcium signaling in the development of alcohol-associated hepatitis (AAH). The project will examine how the expression and localization of the inositol trisphosphate receptor (ITPR) isoforms, particularly ITPR3, impact mitochondrial calcium signals and cellular...
- This Project Grant award of $639,177.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support research to investigate the role of hepatic FOXA3 in the development and progression of alcohol-associated liver disease (ALD). The University of Arizona will conduct this research project to gain a better understanding of the mechanisms underlying the pathogenesis of ALD, which is the most prevalent...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $440,566 to Yale University to advance the treatment of alcohol-associated liver disease (ALD). The primary objective is to uncover therapeutic targets and develop effective ALD treatments, with a focus on the methyltransferase-like (METTL) protein family, notably METTL7A, which is highly expressed in ALD patients. The research utilizes cutting-edge technology...
This federal Project Grant award of $227,844.00 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 Alcohol Research Programs) supports research to elucidate the impact of chronic and excessive alcohol consumption on tumor suppressor genes and their role in the development of alcohol-related liver cancer. The project aims to use both candidate and systemic approaches to identify and characterize key tumor suppressor genes crucial in the pathogenesis of alcohol-related hepatocellular carcinoma (HCC). The research is expected to provide insights that can inform risk assessment, HCC prevention, and therapeutic development. The award was granted to Trustees of Indiana University, doing business as Indiana University Indianapolis, a prominent academic research institution, for the project period of September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $227.8k | 8/22/25 |