Project Grant R21AA031563
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $440,566 to Yale University to advance the treatment of alcohol-associated liver disease (ALD). The primary objective is to uncover therapeutic targets and develop effective ALD treatments, with a focus on the methyltransferase-like (METTL) protein family, notably METTL7A, which is highly expressed in ALD patients. The research utilizes cutting-edge technology...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $253,383 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Yale University to explore the role of the hepatocyte inflammasome in alcoholic liver disease (ALD). This research aims to investigate the liver-specific effects of the inflammasome, a key mediator of inflammation, in hepatocytes - the predominant liver cell type and a driver of ALD pathophysiology. The project will use mouse models to evaluate...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $249,000.00 to East Tennessee State University to characterize acetaldehyde-protein adducts and their effects on lymphocyte function in alcohol-associated liver disease. The research aims to investigate how the ethanol metabolite acetaldehyde forms adducts on proteins, particularly albumin, and how this modulates the pathogenesis of...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,376,398 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Yale University to develop a humanized mouse model to study alcohol-associated hepatitis (AAH). The project aims to create a fully humanized mouse liver system by engrafting human hepatocytes and non-parenchymal cells to better understand the complex cell interactions that drive key features of AAH, a leading cause of liver-related deaths...
- The University of California, San Diego (UCSD) was awarded a $414,750 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to investigate the role of intestinal gp130 signaling in preventing alcohol-associated liver disease. The proposed research aims to define the gp130-STAT3-Reg3 signaling axis involved in protecting against ethanol-induced liver disease and assess the potential of a novel engineered gp130...
- This federal Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 Alcohol Research Programs), supports research to determine the molecular mechanism by which the neutrophilic NCF1 gene and its downstream target miR-223 impact the pathogenesis of alcohol-associated liver disease (ALD). The $249,000 project, awarded to the Trustees of Indiana University, will investigate how neutrophils drive disease severity and mediate liver injury in ALD through the...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $161,000.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The award supports research to investigate the metabolic basis of sarcopenia, or loss of muscle mass, in alcohol-related liver disease (ALD). The key research objectives include using multi-omics analyses to identify global skeletal muscle...
- This federal Project Grant award of $701,051 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The grant supports research to investigate the phenotypes and functions of distinct neutrophil populations in patients with severe alcohol-associated hepatitis (AH). Key objectives include: 1) Characterizing the transcriptomic profiles and functional roles of neutrophil subsets in AH using single-cell RNA sequencing; 2)...
- The federal Project Grant award titled "Role of Functional Iron Deficiency in Alcohol-Associated Liver Disease" is funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The $390,480 award, effective from September 10, 2025 to August 31, 2027, will support research at Emory University to investigate the molecular mechanisms underlying alcohol-associated mitochondrial dysfunction and its role in the progression of...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $248,844 to the University of North Carolina at Chapel Hill (UNC-CH) for research on the use of blood-based RNA biomarkers to diagnose and monitor Alcohol Use Disorder (AUD). The research aims to determine whether blood gene expression profiles can serve as a non-invasive proxy for brain tissue to aid in personalized medicine approaches...
RNA MODIFICATION CHANGES IN ALCOHOL-ASSOCIATED LIVER DISEASE - ABSTRACT. ALCOHOL CONSUMPTION IS A PREDOMINANT ETIOLOGICAL FACTOR IN THE PATHOGENESIS OF CHRONIC LIVER DISEASES. THE PROGRESSIVE NATURE OF ALCOHOL-ASSOCIATED LIVER DISEASE (ALD) HAS BEEN WELL DESCRIBED, BUT THE COMPLEX INTERACTIONS UNDER WHICH THESE PATHOLOGIES EVOLVE REMAIN ONLY PARTIALLY ELUCIDATED. BASED ON OUR PRELIMINARY STUDY, FREE NUCLEOSIDES AND NUCLEOSIDES HYDROLYZED FROM TOTAL RNA ARE ALTERED IN MICE TREATED WITH ALCOHOL AND IN A HUMAN LIVER CELL LINE, HEPARG, TREATED WITH ACETALDEHYDE. WE ALSO OBSERVED SIGNIFICANT CHANGES IN THE SERUM AND URINE OF PATIENTS WITH DIFFERENT STAGES OF ALD. THEREFORE, WE HYPOTHESIZE THAT ALCOHOL CONSUMPTION AFFECTS RNAS' CHEMICAL MODIFICATION AND CONTRIBUTES TO ALD DEVELOPMENT AND PROGRESSION. TO PROVE THIS HYPOTHESIS, WE WILL TREAT MICE WITH ALCOHOL AND FIRST MAP THE CHEMICAL MODIFICATIONS ON RNAS BY ISOLATING DIFFERENT TYPES OF RNAS FROM MOUSE LIVER, DIGESTING THEM INTO NUCLEOSIDES AND OLIGONUCLEOTIDES, AND DETECTING THE SITE- SPECIFIC MODIFICATION ON EACH RNA USING COMPREHENSIVE 2DLC-MS (AIM 1). AND THEN, RNA MODIFICATION VARIATION WILL BE STUDIED BETWEEN ALCOHOL FED AND NORMAL FED MICE AT THE RNA LEVEL, AND THE UNDERLYING MECHANISM WILL BE UNCOVERED BY DETECTING THE EXPRESSION OF THE CORRESPONDING ENZYMES (AIM 2). 1
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $217.0k | 8/25/25 | ||
| Not listed | ($8k) | 10/24/24 | ||
| Not listed | $191.4k | 8/14/24 | ||
| Not listed | $191.4k | 8/14/24 |