This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) is providing $238,445 to the University of Southern California (USC) to conduct research aimed at elucidating the mechanism and significance of translatome alteration as a critical pathophysiology of alcoholic fatty liver (AFL). Through this 2-year exploratory study, the researchers will utilize an in vitro model of terminally differentiated human hepatocytes to determine the molecular mechanisms underlying the dysregulation of translatome in AFL and define the correlation between transcriptome, translatome, and quantitative proteomics of AFL hepatocytes. The overarching goal is to provide unique insights into the pathophysiology of AFL, which represents the initial stage of alcoholic liver disease, and lay the groundwork for further investigation using in vivo models and clinical specimens. The award was granted in May 2024 and is expected to be completed by April 2026.