This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $184,359 to Virginia Commonwealth University (VCU) to evaluate the use of fecal microbiota transplant (FMT) as a potential therapy to reduce ethanol drinking in mice. The key objectives are to assess the effects of microbiota transplant from human donors with varying amounts of beneficial gut bacteria (Lachnospiraceae and Ruminococcaceae) on...
This $510,412.27 project grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) will fund research by the University of Maryland, Baltimore to investigate the role of the gut microbiota in alcohol seeking behaviors and alcohol-induced changes in reward-related decision-making. The key research objectives are to: Determine the role of the gut microbiota in alcohol seeking behaviors using prebiotics and fecal microbial transplants in mouse...
This $194,400 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support research on the effects of adolescent alcohol use on the oral microbiome and brain. The awardee, the Medical University of South Carolina, will recruit 126 adolescents (ages 14-18) with varying levels of alcohol use to collect salivary samples to assess the oral microbiome, with a focus on the Lactobacillus...
The University of California, San Diego (UCSD) was awarded a $414,750 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to investigate the role of intestinal gp130 signaling in preventing alcohol-associated liver disease. The proposed research aims to define the gp130-STAT3-Reg3 signaling axis involved in protecting against ethanol-induced liver disease and assess the potential of a novel engineered gp130...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $131,654 to Biomedit LLC to develop a Lactobacillus-vectored alkaline phosphatase (AP) delivery system to mitigate alcohol-induced leaky gut and endotoxin load. The key goals of this 2-year project are to: 1) Generate engineered live biotherapeutics (ELBPs) that can effectively deliver the proprietary AP enzyme (INPRO) developed by...
This federal Project Grant award, issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), provides $350,000 in funding to Sanford Research North to investigate the biobehavioral mechanisms underlying increased alcohol use following bariatric surgery. The primary objectives are to examine how changes in the gut microbiome and the rewarding effects of alcohol influence the risk of hazardous alcohol use in...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the federal Alcohol Research Programs (CFDA 93.273), provides $698,356 to Brown University to study the relationship between alcohol-associated gut dysbiosis and cardiovascular disease (CVD) risk in people with HIV. The key objectives are to: 1) characterize alcohol-associated gut dysbiosis using whole genome sequencing of fecal samples; 2) examine how gut microbiome changes at the...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) program, provides $499,442 in funding to The Regents of the University of California, San Francisco (UCSF) from August 20, 2024 through July 31, 2027. The award supports research to investigate the role of brain-derived neurotrophic factor (BDNF) signaling in the ventral hippocampus and its contribution to the acute anxiolytic and social...
This federal Project Grant award of $380,863 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports research on the role of specific hepatic stellate cell subsets in the progression of alcohol-associated hepatitis (AH). The project aims to determine how the genes CYP1B1, PRRX1, and NR4A2 regulate the development and function of a novel FBLN2+ activated hepatic stellate cell (AHSC) subset in AH. Planned activities include...
This $213,000 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research conducted by Loyola University of Chicago's Health Sciences Campus to assess the role of nitric oxide synthase 2 (NOS2) and the IL-22-STAT3 signaling pathway in alcohol-mediated exacerbation of ulcerative colitis (UC) pathology. The research aims to determine whether alcohol-induced increases in NOS2 expression directly or...