This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development of a closed-loop deep brain stimulation (DBS) computational framework. The $146,500 award to San Jose State University Research Foundation will be used to:
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Develop novel open-loop DBS techniques targeting neural plasticity to provide long-lasting desynchronization of pathological neuronal activity, particularly for Parkinson's disease.
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Create a new class of multi-input, multi-output closed-loop DBS techniques that use electrophysiological biomarkers as feedback signals to desynchronize excessive, disease-specific neural activity and oscillations in large-scale models of Parkinson's disease and hippocampal neural circuits.
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Develop software tools to integrate the closed-loop DBS framework with electrophysiology hardware.
The award period is from July 2, 2024 to June 30, 2028, and the project aims to enhance understanding of closed-loop DBS for manipulating abnormal neural synchrony and rhythms to enable new neuromodulation protocols for treating brain disorders like Parkinson's disease and epilepsy.
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