This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to investigate the molecular mechanisms underlying fertilization and egg activation in the C. elegans model system. The primary researcher will use a forward genetic screen to identify novel genes involved in sperm-egg binding, fusion, and egg activation. This $133,207 award,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $380,546 to support research on post-transcriptional regulation of gene expression in spermatogonial stem and progenitor cells. The research aims to define how RNA-binding proteins and mRNA degradation mechanisms interact with transcriptional networks to regulate cell state transitions during spermatogenesis, with potential implications...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $498,000 to Worcester Polytechnic Institute to study the modulators and physiological functions of RNA tailing in the C. elegans oocyte. The research aims to identify the terminal nucleotidyl transferases and exonucleases that modulate RNA tails, and elucidate the mechanisms mediating their effects on RNA stability and...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $350,000 to the University of Iowa to support research on the mechanisms involved in the propagation of chromosome fragments in the germline. The 3-year project aims to investigate how DNA breaks that occur during the formation of egg and sperm cells are stabilized and passed on to the next generation. The research will be conducted using the model organism C. elegans and will...
This $508,315 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program supports research to uncover the molecular mechanisms required for successful developmental progression from oocyte to embryo during the window of transcriptional silence in mammals. The project aims to investigate: (I) the mechanisms driving global transcriptional silencing in the oocyte; (II) the post-transcriptional mechanisms...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $565,826 to Duke University to support research on the nutritional control of nematode development. The research aims to elucidate the signaling and gene regulatory mechanisms that enable nematodes (C. elegans) to adapt to fluctuations in nutrient availability, which has implications for understanding growth and quiescence...
This $1,080,375 Project Grant award was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research to define how maternal transcripts and RNA-binding proteins are regulated during oogenesis and early embryogenesis, with a focus on understanding the mechanisms that coordinate maternal regulation in space and time, and how environmental factors like...
This $1,570,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research investigating the mechanisms of RNA-mediated chromatin regulation and transgenerational epigenetic inheritance in the C. elegans model organism. The award will fund two key projects: 1) Investigating the function and enzymology of the novel histone modification H3K23me3, which is induced by the nuclear RNAi pathway...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $381,801 to the University of California, Santa Cruz to conduct research on the mechanisms of nematode molting. The key products and services to be delivered through this 5-year award include: Determining how biological timers control nematode development, focusing on the regulatory roles of NHR-23, LIN-42, and KIN-20. Testing...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to uncover the mechanisms that regulate the transition from germ cells to maternal components during oogenesis. The $1,188,266 award, effective September 1, 2024 through July 31, 2029, will fund research at the Icahn School of Medicine at Mount Sinai to investigate how gene expression changes and genome...