Project Grant R16GM153571
- The National Institute of General Medical Sciences (NIGMS), under the federal Biomedical Research and Research Training program (CFDA 93.859), awarded a $412,500 Project Grant to the University of South Florida. The grant supports a research program focused on understanding the molecular mechanisms of cell death and developing small molecule inhibitors to treat diseases associated with dysregulated cell death, including systemic inflammatory response syndrome (SIRS), infection, and heart...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding research to investigate the role of mechanical cues in the extracellular matrix in regulating monocyte inflammation. The $406,250 award, which runs from January 1, 2025 to December 31, 2029, will support the development of human stem cell-based culture systems to study monocyte mechanobiology, the investigation of mechanical...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Louisville for $108,030.00 supports research on the role of emergency granulopoiesis in wound healing after myocardial infarction. The key objectives are to determine if myocardial infarction-induced emergency granulopoiesis gives rise to neutrophils with differential function, and if emergency granulopoiesis contributes to post-myocardial infarction...
- The federal Project Grant award of $420,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to identify the molecular mechanisms of mitochondrial dysfunction in pathological stress conditions. The primary objective is to investigate the processes of oxidative phosphorylation and mitochondrial membrane potential disruption, which can lead to cell death and tissue damage in various diseases....
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $402,911 Project Grant to The Trustees of Columbia University in the City of New York to develop a pericardial mRNA therapy for the treatment of myocardial infarction (heart attack). The research aims to create a new anti-inflammatory drug based on previous studies of stem cell derivatives for heart repair, which will be administered via minimally invasive...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Albert Einstein College of Medicine provides $785,198 in funding to study the role of chaperone-mediated autophagy (CMA) in regulating cardiac fibroblast and myofibroblast function during heart repair following myocardial infarction. The research aims to investigate how CMA, a selective protein degradation process, modulates fibroblast phenotypic transitions and impacts...
- This Project Grant award, valued at $453,750.00 and awarded on August 8, 2025, supports research by The General Hospital Corporation (doing business as Massachusetts General Hospital) under the National Institute of General Medical Sciences' (NIGMS) Biomedical Research and Research Training program (CFDA 93.859). The research aims to explore how metabolic pathways control the transition between cell viability, pyroptosis (a lytic cell death program), and apoptosis (non-lytic cell death)....
- This federal Project Grant award, valued at $765,288.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The funding supports research at the University of California, San Diego (UCSD) to investigate the biological mechanisms of the infarct borderzone - the complex and dynamic region between areas of cell death and normal tissue in the heart following a myocardial infarction. The research aims to advance...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $771,750 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of California, Los Angeles (UCLA) to investigate the role of macrophages in regulating cardiac muscle metabolism after myocardial infarction. The project aims to shed novel insights into how macrophages recruited to the infarcted heart disrupt cardiac muscle metabolism and lead to decreased NAD pools, which play a critical...
- This federal Project Grant award of $388,000 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Northeastern University. The research aims to develop and validate a new class of engineered macrophages capable of tracking and modulating inflammation in vivo using multi-modal imaging techniques including ultrasound, MRI, and optical imaging. The project will establish a novel framework for...
This Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate the interaction between the proteins MG53 and GSDMD and their role in preventing neutrophil pyroptosis, which can contribute to inflammation and heart cell damage after myocardial infarction. The $155,463 award will fund research with two main objectives: 1) studying how MG53 and GSDMD interact before and after GSDMD activation, and 2) determining if neutrophil pyroptosis contributes to heart cell death. The project will be conducted at St. John's University in New York from September 1, 2025 to May 31, 2029. The findings from this research have the potential to identify new therapeutic approaches for controlling inflammation and promoting healing after a heart attack.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $155.5k | 8/29/25 |