The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $469,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Michigan Technological University. The grant, titled "Dissecting Neural Circuit Mechanisms Underlying Pallidal Deep Brain Stimulation," will fund research to identify the neural elements and circuits necessary for the therapeutic effects of deep brain stimulation (DBS) of the globus pallidus in a Parkinson's disease rat model. The project aims to use a combination of electrical stimulation, optogenetic inhibition, multisite neural recording, and quantitative behavioral assays to determine the functional relevance of GPI-DBS associated neural circuits including the globus pallidus, primary motor cortex, and ventral lateral motor thalamus. The research is expected to provide insight into the neural mechanisms underlying GPI-DBS and establish a framework for developing improved DBS therapies for Parkinson's disease and other neurological disorders.
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