The National Institute of Mental Health (NIMH) awarded a $624,368 Project Grant (CFDA 93.242) to the University of California, San Diego (UCSD) to develop a novel in vivo behavioral and neurophysiological assay for studying risk-taking propensity. The key objectives are to: 1) Optimize an operant task that captures the full spectrum of risk-taking behaviors and identify associated neurophysiological markers, including dopamine receptor 2 expressing medium spiny neuron activity and theta...
This federal Project Grant award of $426,250 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research to investigate the neural circuit basis of safety learning. The primary objectives are to: Test the hypothesis that basolateral amygdala neurons projecting to the insular cortex convey information about safety signals and are necessary for safety learning. Evaluate the hypothesis that infralimbic neurons receiving...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will provide $787,584 to the University of North Carolina at Chapel Hill (UNC-CH) from December 1, 2024 to November 30, 2029. The funding will support research to characterize neurocognitive trajectories of executive function (EF) from infancy to early adulthood, and how these trajectories relate to functional brain organization and psychopathology risk....
This $791,685 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund a longitudinal study investigating neurobehavioral and psychosocial predictors of health risk behaviors (HRBs) from adolescence to young adulthood. The primary goals are to: 1) assess longitudinal associations between brain valuation/control systems and HRBs; 2) examine how childhood poverty, abuse, and neglect impact the developmental...
This $165,980 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a research study examining neural indices of social and monetary reward processing as predictors of real-world pleasure and affect in adolescents at risk for depression. The study aims to determine whether laboratory-based measures of reward outcome processing can predict daily levels of consummatory pleasure and affect among adolescents...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants, supports a comprehensive research study to characterize core computations of value, uncertainty, and prediction error across learning, decision-making, and memory processes, both behaviorally and neurally. The $1,932,991.00 award will fund a behavioral study of 1,000 participants (Aim 1) and a functional MRI study of 100 participants (Aim 2) to examine these...
This $790,712 Project Grant, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to experimentally test the hypothesis that maternal encouragement of child positive emotion will lead to increases in child neural reward response. The grant will support a randomized controlled trial that will train 180 mothers with depression symptoms on positive emotion coaching through the Parent-Child Interaction Therapy-Emotion...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $392,500.00 to the University of California, Irvine to conduct research on the developmental programming of the human hypothalamus and its role in motivated behaviors. The research project, which runs from January 1, 2025 to December 31, 2029, aims to investigate the impact of early life adversity on the structure and function of the developing...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to chart positive valence systems trajectories in offspring of depressed mothers to predict internalizing symptoms in early childhood. The $801,869 award, effective from Sep 1, 2024 to Jun 30, 2029, will use an innovative, multimodal, accelerated longitudinal design to assess neural and behavioral indicators of reward responsiveness in a...
This National Science Foundation (NSF) Project Grant under the Social, Behavioral, and Economic Sciences (CFDA 47.075) program provides $320,000 in funding to Northeastern University for a 5-year research project on the neurocognitive development of adolescent learning. The project aims to investigate the cognitive and brain mechanisms related to learning from experience and how these change from childhood to adolescence and young adulthood. The research will use behavioral, computational, and...