Project Grant R15HL170257
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $772,275 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 25, 2025, with completion targeted for May 31, 2029. This research initiative focuses on investigating endothelial cell scavenger receptor class B type I (SR-BI) regulation and its novel protein interactions in atherosclerosis development. The...
- Federal Grant Award Summary The University of Texas Medical Branch at Galveston received a $788,478 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through June 30, 2029. This research project investigates the role of the C-type lectin pathway, specifically the macrophage galactose-type lectin (MGL/CLEC10A), in regulating immune metabolism within tuberculosis-infected lung...
- The University of Arizona received a $676,459 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, with an ultimate completion date of June 30, 2029. The award funds research investigating the role of hexokinase 3 (HK3) in macrophage polarization and cardiac remodeling following myocardial infarction and ischemia/reperfusion injury. The research utilizes genetically modified...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $1,366,004 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded May 1, 2025, with completion targeted for February 28, 2029. This grant funds research on cholesterol regulation through retriever-dependent low-density lipoprotein (LDL) receptor recycling, addressing the molecular mechanisms by which the RETRIEVER...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $234,000 project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), with award initiation on August 15, 2025, and completion targeted for July 31, 2027. The project delivers scientific research services focused on decoding the force transduction mechanisms of leukocyte-specific integrin LFA-1 (lymphocyte...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of North Carolina at Chapel Hill a Project Grant totaling $233,250 under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025 through August 31, 2027. This award funds research investigating the role of lipid metabolism in lung macrophage activity and phenotypes during acute lung injury. The research project will examine how changes in fatty acid oxidation...
- Federal Project Grant Award Summary Columbia University's Health Sciences Division received a $167,400 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2027. The award funds research investigating an athero-protective pathway mediated by macrophage tryptophan metabolism and aryl hydrocarbon receptor (AHR) activation in atherosclerotic cardiovascular disease....
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Connecticut Health Center a Project Grant totaling $135,930 under the Cardiovascular Diseases Research program (CFDA 93.837) on June 20, 2025, with a completion date of January 31, 2028. This award funds research investigating TRPM7-mediated macrophage signaling in atherosclerosis, a cardiovascular disease responsible for approximately 50% of deaths in Western societies. The...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $1,620,016 Project Grant awarded September 25, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) administered by the National Heart, Lung, and Blood Institute (NHLBI). The award supports research through June 30, 2027, to identify circulating metabolites and biologic pathways linking metabolic dysfunction and ectopic adiposity to cardiac dysfunction and heart failure, with particular...
- Federal Grant Award Summary The University of Texas at Arlington received a $1.37 million Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 1, 2025, through March 31, 2029. The award funds the development of elastic exosome-releasing conductive cardiac patches designed to treat myocardial infarction (MI). The research addresses a critical clinical limitation in existing cardiac patch...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $457,513 to the University of Texas at Arlington (UTA) to investigate the role of the enzyme indoleamine-2,3-dioxygenase 1 (IDO1) and its downstream metabolite kynurenine in regulating cholesterol homeostasis and macrophage function under inflammatory conditions. The 3-year project aims to elucidate the signaling mechanisms linking IDO1, the HDL receptor SR-BI, and cholesterol metabolism in macrophages, as well as examine the in vivo impacts on hepatic inflammation and cholesterol regulation using an animal model. This research seeks to uncover novel pathways connecting lipid metabolism and inflammation in macrophages, which could lead to new therapeutic targets for cardiometabolic diseases. UTA, a Hispanic-Serving Institution, will also leverage this grant to provide research experiences for undergraduate students.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $457.5k | 8/11/23 |