Project Grant R15CA309607
- Federal Project Grant Award Summary Baylor College of Medicine received a $411,404 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on August 20, 2025, with a completion date of July 31, 2027. The grant supports fundamental research aimed at identifying cancer-essential genes through analysis of loss-of-function (LOF) mutations in lung tumors. Specifically, the research applies statistical regression modeling to identify genes...
- Federal Grant Award Summary Baylor College of Medicine received a $160,500 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective July 10, 2025, with completion targeted for June 30, 2027. The award funds the development and investigation of in vivo murine models to examine the role of caspase-2 in nucleophosmin-mutated acute myeloid leukemia (NPM1C+ AML). The research deliverables include the establishment of transgenic mouse...
- Federal Grant Award Summary Baylor College of Medicine received a $147,486 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) effective December 1, 2025, through April 20, 2027. The award supports research and development of RECON (Recombinant Element Control), a novel immune tolerization strategy designed to investigate the relationship between oncogene pathogenicity and immunogenicity in early-stage cancer development. RECON enables...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Baylor College of Medicine a $882,470 Research Specialist (Clinician Scientist) Award under the Cancer Treatment Research program (CFDA 93.395) for the period September 1, 2025 through August 31, 2030. This Project Grant supports the expansion of leadership in the design and conduct of NCI-funded clinical trials for children, adolescents, and young adults with cancer, with particular focus on hematologic malignancies. The...
- Federal Project Grant Award Summary Baylor College of Medicine received a $483,077 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2025 through May 31, 2030. The award supports fundamental research investigating three-dimensional circadian enhancer-promoter interactions mediated by estrogen-related receptor gamma (ESRRG) in the progression from nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC)....
- Federal Project Grant Award Summary Baylor College of Medicine received a $160,000 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective May 1, 2026 through April 30, 2028. The award funds fundamental research aimed at understanding metabolic pathway alterations mediated by SMARCB1 (Switch/Sucrose Non-Fermentable Related Matrix-Associated Actin-Dependent Regulator of Chromatin, Subfamily B, Member 1) loss in metastatic...
- Federal Project Grant Award Summary Baylor University received a $562,499 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2028. The award funds research investigating CTCF-mediated regulation of partial epithelial-mesenchymal transition (EMT) states, a critical cellular plasticity process relevant to development, wound healing, cancer...
- Federal Grant Award Summary Baylor College of Medicine received a $2.4 million Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective August 15, 2025 through July 31, 2029. The award funds research investigating the role of RNA sequestration in acute myeloid leukemia (AML), specifically examining how the RNA helicase DDX6 (DEAD-Box Helicase 6) regulates post-transcriptional processes critical to leukemia development and...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $584,510 to the University of Colorado-Denver on September 12, 2025, under the Cancer Biology Research program (CFDA 93.396) to support the development and implementation of advanced spatial transcriptomics and proteomics technologies for studying tumor microenvironments. Through the Human Immune Monitoring Shared Resource (HIMSR) at the University of Colorado Cancer Center, this funding supports a...
- Federal Grant Award Summary The National Cancer Institute awarded the University of South Alabama a Project Grant totaling $369,868 under the Cancer Biology Research program (CFDA 93.396) to investigate intercellular mitochondrial transfer between nerve cells and triple-negative breast cancer (TNBC) cells at the nerve-cancer interface. Awarded on July 7, 2025, with a completion date of May 31, 2030, this research addresses the functional role of cancer neurogenesis in metastasis and tumor...
Baylor University received a $545,000 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded May 1, 2026, with completion targeted for April 30, 2029. The research project investigates tumor cell autonomous and non-autonomous mechanisms of Lipocalin-2 (LCN2) function in metastasis, addressing a significant gap in understanding how LCN2 promotes solid tumor progression across primary, premetastatic, and metastatic niches. The project applies single-cell spatial proteomic and transcriptomic analysis to characterize LCN2-governed signaling mechanisms, with particular focus on FGFR2 (fibroblast growth factor receptor 2) signaling and adaptive anti-inflammatory immunity in breast and pancreatic cancer contexts. The deliverables under this award include fundamental research findings on the spatiotemporal dynamics of LCN2-dependent mechanisms driving metastatic progression, with the ultimate objective of positioning LCN2 as a biomarker for immune therapy resistance and identifying it as a potential therapeutic target for improving immunotherapy efficacy in immunologically cold tumors. This research aligns with the Cancer Biology Research program's mandate to advance understanding of cancer mechanisms with applications toward improved prevention, detection, diagnosis, and treatment methodologies. The work is performed at Baylor University's facility in Waco, Texas.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $545.0k | 4/10/26 |