This $107,279 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to identify novel small molecule orexin agonists through high-throughput screening of a compound library. The orexin system plays a critical role in functions like sleep and cognition, and orexin deficiency is linked to conditions like narcolepsy, Alzheimer's, and Parkinson's. This project seeks to discover potent, dual-acting orexin agonists that could serve as the basis for new pharmacotherapies to treat neurological disorders associated with orexin deficiency. The award recipient, Research Triangle Institute (RTI International), is an experienced non-profit research organization that has received numerous federal grants and contracts across diverse domains like health, education, and the environment.