The University of South Florida (USF) was awarded a $749,987 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The funding, with an award date of August 15, 2023, supports research to characterize the role of a novel mechanistic pathway involving fibrinogen, sphingolipids, and caveolar transcytosis during traumatic brain injury (TBI) as an example...
This $195,000 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research to determine the mechanism of action for small molecule splicing modulators that may serve as a new therapeutic approach for Huntington's disease. The key objective is to use a combination of cryo-EM structural determination and biochemical methods to...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $483,000.00 over a 5-year period from July 1, 2024 to May 31, 2029 to the University of Florida. The objective of this research is to identify the mechanisms and molecular functions of ribosome stalling in Huntington's disease (HD), which is caused by the polyglutamine...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $136,309 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to the University of California, Irvine (UC Irvine). The grant will fund research to investigate how mutations in the huntingtin (mHtt) gene affect the development and maturation of astrocytes, a critical type of brain cell, in the context of Huntington's disease (HD). The...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $100,060 to the University of Massachusetts Medical School (UMass Medical) to examine the role of a pathogenic Huntingtin (HTT) isoform, HTT1A, in somatic expansion and RNA aggregation in Huntington's disease (HD). The project aims to use small interfering RNA (siRNA) to...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $450,313 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Johns Hopkins University to develop high-throughput screening (HTS) assays to identify activators of the nemo-like kinase (NLK) protein. The goal is to find small molecule compounds that can lower mutant huntingtin (mHTT) protein levels as a potential therapeutic approach for Huntington's...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), provides $345,114 to the University of California, Los Angeles (UCLA) to develop and implement a high-throughput small molecule screening pipeline. The goal is to identify compounds that can reduce the endogenous levels of the MSH3 protein, which has been shown to play a key role in...
Emory University received a $430,375 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to elucidate the subcellular dynamics of ubiquitination, a key biological process regulating synaptic function and neuronal health, using advanced single-molecule imaging techniques. The research aims to uncover new mechanisms by...
This $195,570 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of the molecular co-chaperone DNAJC7 in protein homeostasis and its potential therapeutic implications for neurodegenerative diseases. The 5-year research project, with an award date of August 1, 2024 and a completion date of June 30, 2029, will be...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded Brandeis University a $846,469 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The goal of this 2-year project is to elucidate how the ESCRT (Endosomal Sorting Complex Required for Transport) machinery is regulated and deployed in neurons. The research aims to develop new visualization and manipulation tools to study ESCRT dynamics in...