Project Grant R03HL185218
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1.62 million Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Texas Southwestern Medical Center for research on circulating metabolites underlying cardiometabolic risk and heart failure in diverse populations. Awarded on September 25, 2025, with completion targeted for June 30, 2027, this project will deliver comprehensive metabolomic and genomic analysis services to...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $249,000 Project Grant to The University of Texas Southwestern Medical Center on February 16, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports a three-year research initiative (completion date: January 31, 2029) led by Dr. Chengyi Tu to investigate the molecular mechanisms underlying tachycardia-induced cardiac dysfunction. The research leverages induced...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Texas Southwestern Medical Center a $249,000 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective August 1, 2025, through June 30, 2028, to conduct research investigating the mechanisms of dyspnea on exertion (DOE) and exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF). The research will examine how obesity-related mechanical...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $468,000 Project Grant to The Regents of the University of Colorado-Denver, effective August 1, 2025 through July 31, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837). This award supports secondary analysis research focused on developing noninvasive imaging biomarkers for early prediction of single ventricle failure, a potentially lethal congenital heart defect affecting...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $229,152 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 27, 2025, through March 31, 2028. The grant funds research into the structure, function, and drug treatment of the native cardiac sarcomere in hypertrophic cardiomyopathy (HCM), the most common genetic cardiovascular disorder. The...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $259,446 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 23, 2025, with completion targeted for January 27, 2028. This award supports research aimed at understanding transplant relapse mechanisms in myelodysplastic syndromes (MDS), a heterogeneous group of bone marrow failure disorders...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $212,407 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 16, 2025, with completion targeted by December 21, 2027. The award funds research focused on the functional characterization of NRAC (Nutritionally Regulated Adipose and Cardiac-Enriched Gene), a novel microprotein involved in lipid...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,371,448 Project Grant to The University of Texas Southwestern Medical Center on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds a multi-center observational study examining the association between ventilation quality and cardiac arrest outcomes in out-of-hospital cardiac arrest (OHCA) cases. The primary deliverable is a comprehensive...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $739,466 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through May 31, 2030. This award supports the development of precision Positron Emission Tomography (PET) attenuation correction technology for combined PET/Magnetic Resonance (MR) imaging of cardiac sarcoidosis. The research addresses...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $865,286 to Boston Children's Hospital (The Children's Hospital Corporation) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with a completion date of June 30, 2029. This research initiative will produce a high-resolution spatiotemporal lineage map of cardiac development by integrating advanced lineage tracing, spatial, and single-cell...
The National Heart, Lung, and Blood Institute (NHLBI) awarded $249,000 to The University of Texas Southwestern Medical Center (UT Southwestern) under the Cardiovascular Diseases Research program (CFDA 93.837) for a two-year project grant effective June 1, 2026, through May 31, 2028. Dr. Rachel Leon, an Assistant Professor in the Division of Neonatal-Perinatal Medicine, will lead research investigating the influence of placental hypoxia on inflammatory markers and mediators in fetuses with complex congenital heart disease (CCHD). This R03 award builds upon Dr. Leon's existing K23 mentored research award focused on placental and cerebrovascular hemodynamics in CCHD pregnancies. The project will utilize advanced magnetic resonance imaging (MRI) techniques to examine inflammatory mechanisms in the placenta and assess their impact on fetal brain development. Dr. Leon will leverage her established research infrastructure to recruit pregnant patients from multiple clinical sites, applying her prior discoveries about fetal CCHD placentas to investigate how placental perfusion deficiencies trigger inflammatory responses that may compromise fetal neurologic reserve. The anticipated products include novel findings on the relationship between placental hypoxia and neuroinflammation in CCHD, with the long-term goal of improving neurodevelopmental outcomes in children with complex congenital heart disease by identifying therapeutic intervention points during fetal development.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 5/18/26 |