The National Heart, Lung, and Blood Institute (NHLBI) awarded a $125,250 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The General Hospital Corporation's Research Management Division, doing business as Massachusetts General Hospital (MGH), to study the role of the cytokine FAM3D in regulating cardiac fibrosis and inflammation in heart failure. The 2-year project, led by Dr. James Rhee, will investigate how FAM3D affects cardiac fibroblasts and the lymphatic system, and its potential as a therapeutic target, using animal models of pressure overload and aging-related heart failure. The research aims to provide insights into the pathogenesis of heart failure and identify new treatment approaches.
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