Project Grant R03EB037987
- This Project Grant award of $371,871 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund a biopsychosocial investigation into contemporary human models of postoperative pain. The project aims to gain a deeper understanding of the mechanisms underlying nociception and the pain experience in surgical patients. Key activities include examining endogenous pain modulation, pain neurocircuitry,...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), awarded a Cooperative Agreement of $1,365,701 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop an automated machine learning algorithm called AUTOBPS for continuous monitoring of pain using facial expressions in the Intensive Care Unit (ICU) environment. The project, titled "Continuous Monitoring of Pain Using Facial...
- This $591,122 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research by the Massachusetts Institute of Technology (MIT) to decode and modulate the emotional aspect of pain. Key objectives include: Systematically characterizing autonomic responses to identify signatures for different mouse pain models. Performing in vivo imaging and...
- This is a $5,318,433 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (part of the National Institutes of Health) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund research to investigate the role of the gut microbiome in contributing to individual differences in lumbosacral radicular pain, including pain severity, impact, and persistence after treatment. The research will leverage machine learning techniques to accurately...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund a research project titled "Harnessing Sleep and Biological Rhythms to Improve Postoperative Recovery" at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The $453,750 award, spanning 5 years from September 1, 2025 to August 31, 2030, will support research to understand...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $9,237,770 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University to conduct the "IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain After Surgery" research project. The goal is to gain integrated mechanistic insights into peripheral and central biological processes that contribute to chronic postsurgical pain...
- The Department of the Army Medical Command awarded a $1,509,972 project grant to the Massachusetts General Hospital through the Military Medical Research and Development program. The grant will fund research from September 2022 through September 2025 to assess neuroinflammation in chronic pain using non-invasive microstructural imaging techniques. The Military Medical Research and Development program supports basic, applied, and advanced biomedical research with the goals of transforming...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $3,565,780 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a groundbreaking high-frequency trans-spinal magnetic stimulation (HF-TSMS) system for the non-invasive treatment of neuropathic pain. The funded project aims to create an HF-TSMS tool that can target neural pathways involved in...
- This Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The $226,530 award will support a research project at the University of California, San Francisco (UCSF) focused on using brain stimulation to identify and test network biomarkers for chronic pain relief. The project aims to leverage advanced functional MRI,...
- This federal Project Grant award in the amount of $5,057,591 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to conduct a comprehensive, prospective observational study with 2,400 emergency department patients seeking care for acute pain. The study aims to: 1) characterize clinically-informed pain phenotypes, 2)...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $178,856 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research aimed at developing an interpretable and predictive model for post-surgical pain (P-SP) outcomes. The project will leverage multimodal data, including functional neuroimaging, psychological, behavioral, and medical history, to identify the most predictive features of P-SP and apply Shapley value analysis to interpret the contributions of each feature to the predictions. This is expected to facilitate early identification of patients at risk for chronic pain and enable more targeted interventions, ultimately transforming post-surgical care. The award period runs from September 1, 2025, to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $178.9k | 8/8/25 |