This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...
This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
This federal Project Grant award of $129,420.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research by The Leland Stanford Junior University (Stanford University) to advance the understanding and treatment of cleft palate bone regeneration. The key focus of the research is to: Investigate how differences in skeletal stem cell subpopulations and bone morphogenetic protein receptor...
This federal Project Grant award, valued at $161,762.00 and awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the role of the NG2/CSPG4 protein in the healing of endochondral fractures in the mandible. The research aims to define the specific molecular pathways by which NG2/CSPG4 regulates the differentiation of osteochondral progenitor cells during fracture repair, with the...
This federal Project Grant award of $424,560 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support research to investigate the effects of the natural compound hesperidin on bone regeneration and bone morphogenetic protein (BMP) function. The University of North Carolina at Chapel Hill will utilize an innovative 3D co-culture platform to simulate the bone microenvironment and understand...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), is focused on regeneration of alveolar bone tissue. The $476,287 award aims to investigate the role of the MERTK receptor tyrosine kinase in regulating early bone formation and its potential as a therapeutic target for alveolar bone regeneration. Specific objectives include determining the effects of MERTK...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $447,009 to Georgia Tech Research Corp to develop a biomaterial-based delivery platform that can facilitate the transfer of exogenous mitochondria to osteoprogenitor cells to promote bone regeneration. The goal is to create a novel approach to improve therapies for craniofacial bone defect regeneration by harnessing the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,325,889 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Southern California on September 19, 2024. This grant, titled "Regulating Skeletal Connectivity in Craniofacial Development and Disease," will support a comprehensive and forward-thinking research program led by Dr. Amy Merrill that investigates the craniofacial skeleton as a multi-tissue...
This federal Project Grant award of $685,594 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to leverage microsurgery and bioprinting techniques to improve vascularization and survival of 3D printed or bioprinted bone grafts for craniomaxillofacial reconstructive surgery. The key products and services to be delivered include: Developing a novel microsurgical "vascular micropuncture"...
The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded Matregenix Inc. a $976,000 project grant (Award ID R44DE035026) to develop MATRINOVA, an animal-free, amino acid-based biodegradable barrier membrane for guided bone regeneration in dental and craniomaxillofacial surgeries. The goal is to establish the efficacy and clinical significance of MATRINOVA, a bilayered membrane produced using...