Project Grant R03CA313537
- Federal Project Grant Award Summary The University of Texas at Austin received a $668,878 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) on April 3, 2026, with completion scheduled for March 31, 2031. This award funds the development of a novel antibody-drug conjugate (ADC)-based therapeutic platform targeting CD44 variant 9 (CD44V9) to treat aggressive and treatment-resistant breast cancer, particularly triple-negative and...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Texas at Austin a $2.59 million Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective August 1, 2025, through July 31, 2029. The award supports research to develop a novel cancer immunotherapy approach targeting immune-excluded or "cold" tumors that typically demonstrate poor response to immune checkpoint therapy. The project focuses on demonstrating that degradation of...
- Federal Grant Award Summary The National Cancer Institute awarded a $396,377 Project Grant to the University of Texas at Austin on May 7, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to characterize mutational signatures at hotspots of genetic instability in human cancer genomes. The research project, with a completion date of April 30, 2028, integrates large-scale cancer genome analyses, gene perturbation experiments, and environmental mutagen exposure data to...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $639,514 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective June 1, 2026, through May 31, 2031. This five-year research initiative focuses on mechanistic characterization of benzothiazepinone inhibition of NVL (Norovirus-Like), an essential AAA+ adenosine triphosphatase (ATPase) enzyme involved in ribosomal large subunit (60S)...
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $370,173 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded September 9, 2025, with a completion date of August 31, 2030. This project delivers research and development of advanced genetic interaction measurement and characterization methodologies for cancer cells, with a primary focus on synthetic lethality as a...
- Federal Project Grant Award Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded a $164,000 Project Grant to The University of Texas MD Anderson Cancer Center, effective September 1, 2025, through August 31, 2027. This award supports research investigating the clonal determinants of platinum/PARP inhibitor (PARPi) cross-resistance in high-grade serous ovarian cancer (HGSOC). The research utilizes a novel somatic mosaic genetically-engineered mouse model...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $402,011 Project Grant to The University of Texas Southwestern Medical Center under the Cancer Biology Research program (CFDA 93.396) for the period May 1, 2026 through April 30, 2031. This five-year research project investigates the molecular mechanisms by which the KEAP1-NRF2 (Kelch-like ECH-associated protein 1–Nuclear factor erythroid 2-related factor 2) redox-sensing pathway regulates CD8 T cell adaptation to...
- Federal Grant Award Summary The National Cancer Institute awarded The University of Texas MD Anderson Cancer Center a $420,400 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective August 1, 2025, through July 31, 2027. This award supports exploratory studies investigating cellular resistance mechanisms to second-generation MTA-cooperative PRMT5 inhibitors (MTA:PRMT5I) in MTAP-loss tumors. The research addresses a critical clinical challenge whereby 40-60% of patients...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $421,685 Project Grant under the Cancer Biology Research program (CFDA 93.396) to The University of Texas MD Anderson Cancer Center, effective August 1, 2025, through July 31, 2027. This award supports pan-cancer analysis of convergent immunoglobulins from tumor-infiltrating B cells (TIL-B), with the primary deliverable being the identification and characterization of shared B cell receptors (BCR) and antibodies across...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $688,073 to The University of Texas MD Anderson Cancer Center on June 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to support a five-year project through May 31, 2031. Under the direction of Principal Investigator Dr. Peter Van Loo, this project will develop novel computational approaches to reconstruct the evolutionary history of cancer metastases. The research leverages DNA sequencing and molecular...
The National Cancer Institute awarded the University of Texas at Austin a $150,898 Project Grant under the Cancer Biology Research program (CFDA 93.396) on June 8, 2026, for a two-year research initiative focused on identifying novel mediators of cell-cell fusion in triple negative breast cancer (TNBC). The project addresses a critical gap in TNBC treatment by investigating how ploidy-altering mechanisms, particularly cell-cell fusion and whole genome doubling, drive intratumoral heterogeneity and chemotherapeutic resistance. The research will deliver fundamental discoveries through two primary research aims: a pooled CRISPR activation screen to identify genes promoting homotypic cell-cell fusion in TNBC cells, and validation of candidate fusion drivers through live-cell imaging and an arrayed CRISPR activation screen. These investigative products are designed to reveal targetable regulators of cancer cell-cell fusion that could provide new therapeutic strategies for TNBC progression. This focused, two-year research effort is structured to generate preliminary data for future mechanistic investigations of cancer cell-cell fusion, with anticipated progression to a larger R01 or similar National Institutes of Health application. The award concludes on May 30, 2028, and positions the University of Texas at Austin's research capabilities to advance understanding of understudied cell fusion processes in one of the most aggressive breast cancer subtypes, which accounts for 15-20% of diagnosed breast cancers and currently lacks targeted treatment options.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $150.9k | 6/9/26 |