This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $177,209 to Temple University to develop a class of chemical probes that can effectively inhibit c-Myc, an important target for treating castration-resistant prostate cancer (CRPC). The project aims to utilize a proprietary fluorine-thiol displacement reaction (FTDR) stapling technique to generate peptide mimetics that can disrupt c-Myc-Max heterodimerization and c-Myc-mediated transcriptional activity in CRPC cells. The goal is to create a toolbox of c-Myc-targeted cellular probes that can help systematically dissect c-Myc-driven drug resistance and facilitate future therapeutic development for CRPC treatment or as adjuvants to androgen receptor (AR) antagonists. The award period runs from July 18, 2025 to June 30, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $177.2k | 7/18/25 |