This $628,000 project grant from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), aims to investigate how Alzheimer's disease (AD) pathogenesis interferes with synaptic autophagy, and whether optimizing synaptic autophagy can be neuroprotective in an AD mouse model.
The grant recipient, Rutgers The State University of New Jersey, will utilize primary hippocampal cell cultures from an AD mouse model to determine which step in the autophagic processing of synaptic proteins is disrupted by AD-associated changes. Additionally, the researchers will evaluate if overexpressing the proteins RAB26 and/or bassoon in the mouse brain can provide neuroprotective benefits in the AD model. The research incorporates biochemical, histochemical, cell biological, genetic, and behavioral approaches to gain insights into the role of synaptic autophagy in AD pathogenesis and potential therapeutic strategies. The grant period runs from January 1, 2025 through December 31, 2026.
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