This $880,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to examine the effects of daily stress, sleep, and sex hormones on accelerated vascular aging in premenopausal midlife women. The 2-year study, starting November 2024, will investigate how emotional reactivity to daily stressors and sleep variability contribute to vascular dysfunction prior to menopause, and how these factors interact with changes in estradiol levels. The...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $245,434 to Wake Forest University Health Sciences to examine the associations between early and later-life stress on later-life cognition and plasma biomarkers of Alzheimer's disease and related dementias (ADRD). The study aims to assess whether sex modifies these associations in a cohort of community-dwelling participants without dementia recruited into the Wake Forest Alzheimer's...
This Project Grant award of $794,978.00 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support a longitudinal study to examine accelerated epigenetic aging as a mechanism linking socioeconomic disadvantage across the lifespan to cognitive decline in midlife. The research will leverage the Adult Health and Behavior Project's existing data on individual socioeconomic status, neuropsychological assessments, and stored blood samples to analyze...
This National Science Foundation (NSF) Project Grant under the Social, Behavioral, and Economic Sciences program (CFDA 47.075) provides $648,655 in funding to Miami University to investigate how childhood experiences, such as maltreatment and parenting quality, predict daily emotional reactivity to stress in adulthood. The research aims to inform the design of interventions to help people respond constructively to daily stress. The project builds on the long-running Minnesota Longitudinal...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University from November 2024 to January 2026 to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will use a multilevel, multimodal framework including behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research supports a research study to determine how biological sex influences the self-renewal of B1 cells, a subset of B cells that produce natural antibodies, in aged mice and humans. The goal is to elucidate the mechanisms behind differential B1 cell self-renewal in aged males versus aged females, which could inform strategies to maintain healthy natural immunity into old age. The $1,526,780 award,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $459,250 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct a longitudinal study investigating the impact of stress and resilience on Alzheimer's disease-related brain pathology and cognitive function. The research aims to elucidate the sequential relationships between stress, resilience, and the development of Alzheimer's disease over time,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $127,386 to Yale University from June 1, 2025 to March 31, 2030 to conduct a longitudinal study evaluating the impact of chronic stress on synaptic changes in an animal model using in vivo positron emission tomography (PET) imaging. The study aims to determine the effect of chronic stress on synaptic density, investigate the impact of age on stress-induced synaptic changes, and explore...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $158,918 to Vanderbilt University to conduct a multi-omic study exploring the impact of lifestyle variation on immunological aging patterns. The study will focus on characterizing age-associated molecular phenotypes such as gene expression, DNA methylation, and clonal hematopoiesis in peripheral blood samples collected from subsistence-level populations (Tsimane, Turkana, Orang Asli) and a...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $153,512.00 to the Regents of the University of Minnesota to conduct research on the relationship between lipid metabolism, mitochondrial stress, and cellular senescence. The key objectives are to: 1) use proteomics to characterize mitochondrial protein targets of carbonylation during obesity and aging, and 2) investigate the role of mitochondrial stress and signaling on adipose tissue...