This $341,000 Project Grant award from the National Institute on Aging's Aging Research (CFDA 93.866) program supports research by The Roskamp Institute, Inc. in Sarasota, Florida to investigate the impact of the APOE4 gene variant on brain bioenergetics and potential treatments for Alzheimer's disease. The research aims to examine how APOE4-mediated disturbances in fatty acid oxidation pathways within cerebrovascular cells and astrocytes may contribute to neuronal energy supply deficits in APOE4 carriers, especially in the presence of Alzheimer's-related pathology. The project will evaluate whether targeting the GLP-1R-AMPK-ACC pathway in these cell types can regulate fatty acid oxidation and correct bioenergetic imbalances, which could inform new therapeutic approaches for Alzheimer's disease in high-risk APOE4 individuals. The award period is from January 1, 2025 to December 31, 2026.
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