This $310,000 federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research program), supports research at Texas Tech University Health Sciences Center (TTUHSC) on alternative polyadenylation of mRNA and its impact on the development and progression of Alzheimer's disease (AD).
The key objectives are to: 1) identify AD-associated alternative polyadenylation genes and pathways using computational analysis of existing single-cell RNA sequencing datasets, and 2) validate prioritized alternative polyadenylation genes in postmortem prefrontal cortex samples from AD and non-symptomatic donors using in situ hybridization. This research aims to elucidate the molecular mechanisms underlying AD pathology and provide a foundation for developing innovative pharmacological interventions. The award is effective from September 2024 through August 2026.
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