Project Grant R03AG085084
- This Project Grant award of $409,612 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) will support research investigating the neurobiological mechanisms underlying self-regulation and pain catastrophizing in chronic pain patients, with a focus on fibromyalgia. The primary research objectives are to: (1) evaluate the effect of cognitive-behavioral therapy (CBT) on neural mechanisms of catastrophizing self-regulation, assessed using real-time fMRI...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $9,237,770 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University to conduct the "IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain After Surgery" research project. The goal is to gain integrated mechanistic insights into peripheral and central biological processes that contribute to chronic postsurgical pain...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $6,522,833 Project Grant to The Leland Stanford Junior University to conduct a mechanistic randomized clinical trial investigating the central and peripheral nervous system mechanisms of pain relief induced by peripheral nerve stimulation (PNS) for the treatment of refractory chronic neuropathic pain. The 3-year study, funded under the NIH HEAL Initiative's CFDA 93.279 Drug Abuse and Addiction Research Programs, aims...
- This Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The $226,530 award will support a research project at the University of California, San Francisco (UCSF) focused on using brain stimulation to identify and test network biomarkers for chronic pain relief. The project aims to leverage advanced functional MRI,...
- The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,643,228 Cooperative Agreement grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to Worcester Polytechnic Institute (WPI) to develop an Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment (IMPACT). The key objectives of this 2-year IMPACT project are to: 1) Initiate a clinical trial of Mindfulness-Based Stress Reduction (MBSR) for chronic low back pain...
- This Project Grant award of $4,649,740 from the National Institute of Neurological Disorders and Stroke (part of the National Institutes of Health) under the Drug Use and Addiction Research Programs (CFDA 93.279) is funding research to develop network-based models for understanding inter-individual differences in the progression of chronic musculoskeletal pain, using knee osteoarthritis as a case study. The research aims to: 1) Use natural language processing to annotate patient narratives and...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $246,750 to The Trustees of Columbia University in the City of New York, Health Sciences Division, to research the role of the mesocortical glutamatergic pathway in the development and maintenance of chronic neuropathic pain. The project aims to use in vivo imaging,...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), provides $3,473,616 to the University of Connecticut to develop a novel implantable neuromodulation system called "SmartStim" to treat chronic pain. The goal is to create a combined device and drug treatment that can selectively block sensitized nociceptive (pain-sensing) nerve fibers, especially C-fibers, to reverse the underlying neural...
- This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop a guided, web-based intervention combining Acceptance and Commitment Therapy (ACT) for chronic pain and Mindfulness-Based Relapse Prevention (MBRP) for substance use disorders. The $188,307 award, effective September 1, 2025 through August 31, 2029, will support the principal investigator Dr. Edwards and her mentorship team at...
- This Project Grant award of $238,685 from the National Institute of Neurological Disorders and Stroke (CFDA 93.279 - Drug Use and Addiction Research Programs) supports research by the University of California, San Francisco (UCSF) to investigate sex-dependent modulation of pain pathways by regulatory T cells. The research aims to elucidate how sex hormones and pregnancy influence an opioid signaling circuit in the spinal cord meninges that confers antinociceptive effects in female mice. This...
FOSTERING KNOWLEDGE TRANSLATION OF NEUROPLASTICITY-TARGETED INTERVENTIONS FOR CHRONIC PAIN MANAGEMENT USING ADVANCED META-ANALYTIC METHODS AND STATISTICAL LEARNING - SUMMARY CHRONIC PAIN IS ONE OF THE MOST PREVALENT DISEASES AND THE LEADING CAUSE OF DISABILITY WORLDWIDE. GIVEN ITS HIGH INTER-PATIENT VARIABILITY TO RESPONSE TO TREATMENT, INEFFECTIVENESS OF AVAILABLE PAIN MEDICATION TO COMPLETELY RELIEVE CHRONIC PAIN, AND UNEQUAL AVAILABILITY OF PAIN TREATMENTS FOR UNDERREPRESENTED POPULATIONS, IT REMAINS A BURDENSOME, DIFFICULT TO TREAT CONDITION. IN THIS CONTEXT, NEUROPLASTICITY-TARGETED INTERVENTIONS (NTIS) ARE BEING INVESTIGATED AS A POTENTIAL SOLUTION FOR THE CURRENT ISSUES WITH CHRONIC PAIN. THEY ARE A GROUP OF DIVERSIFIED THERAPIES THAT MODULATE NEUROPLASTICITY OF PAIN-RELATED PATHWAYS THROUGH BOTTOM-UP OR TOP-DOWN APPROACHES. ALTHOUGH SIGNIFICANT EFFECTS OF ELECTRICITY-BASED TECHNIQUES SUCH AS TRANSCRANIAL DIRECT CURRENT STIMULATION (TDCS) HAVE BEEN EVIDENCED FOR PAIN REDUCTION IN DIFFERENT CHRONIC PAIN CONDITIONS, THERE IS HIGH INTER-TRIAL VARIABILITY REGARDING THESE RESULTS WITH DIFFERENT COMBINED NTIS. THEREFORE, GIVEN THE HARD-TO-TREAT NATURE OF CHRONIC PAIN AND THE UNKNOWN OPTIMAL COMBINATION OF NTIS, THIS PROPOSED PROJECT SUGGESTS A MULTIPHASE OPTIMIZATION STRATEGY TO ASSESS THE DIRECT AND INDIRECT COMPARATIVE EFFECTS OF NTIS (AND THEIR COMPONENTS) IN CHRONIC PAIN, AND TO DEVELOP A TREATMENT HIERARCHY USING LIVING BAYESIAN NETWORK META-ANALYSES (AIM 1). THESE META-ANALYSES WILL PROVIDE THE FRAMEWORK FOR THE DEVELOPMENT OF SUPERVISED MACHINE LEARNING MODELS TO PREDICT ANALGESIC RESPONSE TO NTIS IN CHRONIC PAIN (AIM 2). AIM 2 WILL BE CARRIED OUT WITH THE USE OF SECONDARY, CLINICAL, AND NEUROPHYSIOLOGICAL DATA FROM 14 CLINICAL TRIALS WITH 669 PATIENTS TO IMPLEMENT MULTILEVEL MODELING CONSIDERING DIFFERENT CHRONIC PAIN PREDICTORS SHARED AMONG DIFFERENT CHRONIC PAIN CONDITIONS AND TYPES OF INTERVENTIONS. BOTH EVIDENCE BODIES (NETWORK META-ANALYSES AND PREDICTIVE MODELS) WILL BE DEPLOYED IN AN OPEN ACCESS WEB-BASED PLATFORM, WHICH WILL FACILITATE THE CONSTANT UPDATE (MONTHLY) AND DATA SHARING TO A BROAD USER POPULATION. MY EXPERTISE AND BACKGROUND IN META-RESEARCH, DATA SCIENCE, NEUROMODULATION, AND CHRONIC PAIN RESEARCH WILL ALLOW ME TO FULFILL THIS PROJECT'S AIMS WITH NO FORESEEABLE OBSTACLES. MOREOVER, I WILL BE WORKING WITH COLLABORATORS FROM SPAULDING NEUROMODULATION CENTER AND UNIVERSITY OF SAO PAULO THAT HAVE BEEN SIGNIFICANTLY INVOLVED IN STUDIES CONVEYING THE PROMISING EFFECTS OF NTIS FOR THE REDUCTION OF CHRONIC PAIN. THEREFORE, THE R03 AWARD WILL PROVIDE PRELIMINARY DATA FOR FURTHER FUNDING APPLICATION AND PROMOTE THE PRECISION PAIN MANAGEMENT APPROACH VIA DATA SHARING AND FUSION APPROACHES.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $170.0k | 5/22/24 |